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解读和交流肿瘤学临床试验的流行病学和统计学考量

Epidemiological and statistical considerations for interpreting and communicating oncology clinical trials.

作者信息

Heller Jane

机构信息

School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga 2650 Australia.

出版信息

Vet J. 2015 Aug;205(2):233-7. doi: 10.1016/j.tvjl.2015.02.014. Epub 2015 Feb 24.

Abstract

The use of randomised controlled trials (RCTs) in veterinary oncological research and practice is increasing as is the number of relevant scientific publications. While clear guidelines exist for the reporting of RCTs, a thorough understanding of statistical and epidemiological concepts is required in order to accurately interpret and then impart the results of such trials, and to make balanced decisions regarding the uptake of published findings. This review presents the most important epidemiological and statistical considerations that are needed in order to interpret and communicate with confidence the results of oncology clinical trials.

摘要

随机对照试验(RCTs)在兽医肿瘤学研究与实践中的应用正在增加,相关科学出版物的数量也在增加。虽然存在关于RCT报告的明确指南,但为了准确解释并传达此类试验的结果,并就是否采用已发表的研究结果做出权衡决策,需要对统计学和流行病学概念有透彻的理解。本综述介绍了解释肿瘤学临床试验结果并自信地进行交流所需考虑的最重要的流行病学和统计学因素。

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