Xu Bing, Sun Duoxiang, Wang Zhihua, Weng Haiyan, Wu Dabao, Zhang Xuefen, Zhou Ying, Hu Weiping
Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China.
Department of Pathology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China.
Hum Pathol. 2015 Jun;46(6):858-67. doi: 10.1016/j.humpath.2015.02.012. Epub 2015 Mar 5.
Epithelial ovarian cancer is composed of a diverse group of tumors that can be derived from the fallopian tube, endometrium, or ovary. In this study, we explored the expression levels of LATS family members in ovarian tumors using normal ovaries, fallopian tubes, and endometrium as controls. Immunohistochemistry studies of LATS1, LATS2, Pax8, and calretinin were performed on normal ovary, fallopian tube, normal endometrium, and ovarian tumor sections. Statistical analyses were conducted using the χ(2) test, Fisher exact test, or Kruskal-Wallis H test. Patient survival was analyzed using the Kaplan-Meier method. LATS1 was expressed in normal ovarian epithelia, endometrium, and fallopian tubes, whereas LATS2 expression was observed in the normal fallopian tubes and endometrium. High expressions of LATS1 and LATS2 in serous cystadenomas gradually decreased in borderline cystadenomas and carcinomas, respectively. However, an opposite expression pattern was observed in mucinous tumors. Low expressions of LATS1 and LATS2 were also detected in clear cell carcinoma. Both LATS1 and LATS2 expression levels significantly correlated with recurrence and stage; LATS1 levels were also related with tumor grades in serous carcinoma. However, univariate and multivariate Cox regression analyses revealed that high expression of LATS1 was associated with better prognosis in patients with serous carcinoma. Both LATS1 and LATS2 were not related with the clinical variables in mucinous and clear cell carcinoma. LATS1 expression levels might be a valuable survival indicator in ovarian serous carcinoma.
上皮性卵巢癌由多种肿瘤组成，这些肿瘤可能起源于输卵管、子宫内膜或卵巢。在本研究中，我们以正常卵巢、输卵管和子宫内膜作为对照，探讨了LATS家族成员在卵巢肿瘤中的表达水平。对正常卵巢、输卵管、正常子宫内膜和卵巢肿瘤切片进行了LATS1、LATS2、Pax8和钙视网膜蛋白的免疫组织化学研究。使用χ(2)检验、Fisher精确检验或Kruskal-Wallis H检验进行统计分析。采用Kaplan-Meier法分析患者生存率。LATS1在正常卵巢上皮、子宫内膜和输卵管中表达，而LATS2在正常输卵管和子宫内膜中表达。浆液性囊腺瘤中LATS1和LATS2的高表达在交界性囊腺瘤和癌中分别逐渐降低。然而，在黏液性肿瘤中观察到相反的表达模式。在透明细胞癌中也检测到LATS1和LATS2的低表达。LATS1和LATS2的表达水平均与复发和分期显著相关；LATS1水平也与浆液性癌的肿瘤分级有关。然而，单因素和多因素Cox回归分析显示，LATS1高表达与浆液性癌患者的较好预后相关。LATS1和LATS2均与黏液性和透明细胞癌的临床变量无关。LATS1表达水平可能是卵巢浆液性癌中一个有价值的生存指标。
