由梅利亚链霉菌产生的新型抗肿瘤抗生素化合物AT2433 - A1、AT2433 - A2、AT2433 - B1和AT2433 - B2。分类学、发酵、分离及生物学特性。

AT2433-A1, AT2433-A2, AT2433-B1, and AT2433-B2 novel antitumor antibiotic compounds produced by Actinomadura melliaura. Taxonomy, fermentation, isolation and biological properties.

作者信息

Matson J A, Claridge C, Bush J A, Titus J, Bradner W T, Doyle T W, Horan A C, Patel M

机构信息

Pharmaceutical Research and Development Division, Bristol-Myers Company, Wallingford, Connecticut 06492.

出版信息

J Antibiot (Tokyo). 1989 Nov;42(11):1547-55. doi: 10.7164/antibiotics.42.1547.

DOI:10.7164/antibiotics.42.1547

PMID:2584136

Abstract

Compounds AT2433-A1 (A1), AT2433-A2 (A2), AT2433-B1 (B1), and AT2433-B2 (B2) were isolated from the cultured broth of Actinomadura melliaura sp. nov. (SCC 1655). Structurally these materials are closely related to rebeccamycin (1), an indolocarbazole antitumor antibiotic. A1, A2, B1, and B2 were active against Staphylococcus aureus A9537, Streptococcus faecalis A20688, Streptococcus faecium (ATCC 9790), Micrococcus lutea (ATCC 9341), Bacillus subtilis (ATCC 6633). A1 and B1 were active against P388 leukemia in mice.

摘要

化合物AT2433 - A1（A1）、AT2433 - A2（A2）、AT2433 - B1（B1）和AT2433 - B2（B2）是从新种梅利亚链霉菌（SCC 1655）的培养液中分离得到的。从结构上看，这些物质与吲哚咔唑类抗肿瘤抗生素瑞贝卡霉素（1）密切相关。A1、A2、B1和B2对金黄色葡萄球菌A9537、粪肠球菌A20688、屎肠球菌（ATCC 9790）、藤黄微球菌（ATCC 9341）、枯草芽孢杆菌（ATCC 6633）具有活性。A1和B1对小鼠P388白血病具有活性。