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LL-D49194抗生素，一类新型抗肿瘤药物：分类学、发酵及生物学特性

LL-D49194 antibiotics, a novel family of antitumor agents: taxonomy, fermentation and biological properties.

作者信息

Maiese W M, Labeda D P, Korshalla J, Kuck N, Fantini A A, Wildey M J, Thomas J, Greenstein M

机构信息

Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.

出版信息

J Antibiot (Tokyo). 1990 Mar;43(3):253-8. doi: 10.7164/antibiotics.43.253.

DOI:10.7164/antibiotics.43.253
PMID:2324010
Abstract

A novel family of antitumor antibiotics, designated LL-D49194, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces vinaceus-drappus. LL-D49194 alpha 1 and beta 2 were active against Gram-positive and inactive against Gram-negative bacteria in vitro. The beta 1 component was not active against either Gram-positive or Gram-negative bacteria. These antibiotics exhibited significant in vivo activities against several murine tumors, albeit with differing potencies.

摘要

从一株鉴定为酒红链霉菌的放线菌发酵液中分离出了一个新的抗肿瘤抗生素家族，命名为LL-D49194。LL-D49194 α1和β2在体外对革兰氏阳性菌有活性，对革兰氏阴性菌无活性。β1组分对革兰氏阳性菌和革兰氏阴性菌均无活性。这些抗生素对几种小鼠肿瘤显示出显著的体内活性，尽管效力不同。

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