阿替米星，一种新型杀螨和抗肿瘤物质。II. 结构测定。

Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.

作者信息

Takahashi A, Ikeda D, Nakamura H, Naganawa H, Kurasawa S, Okami Y, Takeuchi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1989 Nov;42(11):1562-6. doi: 10.7164/antibiotics.42.1562.

DOI:10.7164/antibiotics.42.1562

PMID:2584138

Abstract

The structure of altemicidin, a new acaricidal and antitumor agent, was determined to be (1R,2S,3aR,7aS)-4-carbamoyl-2-hydroxy-6-methyl-1-(sulfamo ylacetamido)-2,3,3a,6, 7,7a-hexahydro-6-azaindene-1-carboxylic acid by a combination of spectroscopic and X-ray crystallographic analysis of its derivatives. Altemicidin is a monoterpene alkaloid.

摘要

新型杀螨和抗肿瘤药物多杀菌素的结构，通过对其衍生物的光谱分析和X射线晶体学分析相结合的方法，确定为(1R,2S,3aR,7aS)-4-氨甲酰基-2-羟基-6-甲基-1-(氨磺酰基乙酰氨基)-2,3,3a,6,7,7a-六氢-6-氮杂茚-1-羧酸。多杀菌素是一种单萜生物碱。