Microbial conversion of anthracyclinones to carminomycins by a blocked mutant of Actinomadura roseoviolacea.
作者信息
Nakagawa M, Hayakawa Y, Imamura K, Seto H, Otake N
机构信息
Institute of Applied Microbiology, University of Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1989 Nov;42(11):1698-703. doi: 10.7164/antibiotics.42.1698.
PMID:2584152
Abstract
New anthracycline antibiotics, 1-hydroxy-11-deoxycarminomycin II and 11-deoxycarminomycin II were produced by a blocked mutant MuW1 of Actinomadura roseoviolacea from epsilon-pyrromycinone and aklavinone, respectively. We found that the enzyme catalyzing hydroxylation at the C-11 position was not lost but was down regulated in the strain MuW1.
摘要
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