危重新生儿的血流动力学监测：展望未来。

Hemodynamic monitoring of the critically ill neonate: An eye on the future.

作者信息

Azhibekov Timur, Soleymani Sadaf, Lee Ben H, Noori Shahab, Seri Istvan

机构信息

Division of Neonatology and the Center for Fetal and Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles and the LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Sidra Medical and Research Center, Doha, Qatar.

出版信息

Semin Fetal Neonatal Med. 2015 Aug;20(4):246-54. doi: 10.1016/j.siny.2015.03.003. Epub 2015 Apr 1.

DOI:10.1016/j.siny.2015.03.003

PMID:25841985

Abstract

By continuous assessment of dynamic changes in systemic and regional perfusion during transition to extrauterine life and beyond, comprehensive neonatal hemodynamic monitoring creates numerous opportunities for both clinical and research applications. In particular, it has the potential of providing additional details about physiologic interactions among the key hemodynamic factors regulating systemic blood flow and blood flow distribution along with the subtle changes that are frequently transient in nature and would not be detected without such systems in place. The data can then be applied for predictive mathematical modeling and validation of physiologically realistic computer models aiming to identify patient subgroups at higher risk for adverse outcomes and/or predicting the response to a particular perturbation or therapeutic intervention. Another emerging application that opens an entirely new era in hemodynamic research is the use of the physiometric data obtained by the monitoring and data acquisition systems in conjunction with genomic information.

摘要

通过持续评估向宫外生活过渡及之后全身和局部灌注的动态变化，全面的新生儿血流动力学监测为临床和研究应用创造了众多机会。特别是，它有可能提供有关调节全身血流和血流分布的关键血流动力学因素之间生理相互作用的更多细节，以及那些本质上常常是短暂的细微变化，而没有这样的系统则无法检测到这些变化。然后，这些数据可应用于预测性数学建模以及对生理逼真的计算机模型进行验证，旨在识别不良结局风险较高的患者亚组和/或预测对特定干扰或治疗干预的反应。血流动力学研究中另一个开启全新时代的新兴应用是将监测和数据采集系统获得的生理测量数据与基因组信息结合使用。