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既往A型主动脉夹层修复术后的主动脉弓手术:长达5年的结果

Aortic arch surgery after previous type A dissection repair: results up to 5 years.

作者信息

Bajona Pietro, Quintana Eduard, Schaff Hartzell V, Daly Richard C, Dearani Joseph A, Greason Kevin L, Pochettino Alberto

机构信息

Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA Division of Cardiovascular Surgery and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA Department of Cardiovascular Surgery, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.

出版信息

Interact Cardiovasc Thorac Surg. 2015 Jul;21(1):81-5; discussion 85-6. doi: 10.1093/icvts/ivv036. Epub 2015 Apr 4.

Abstract

OBJECTIVES

Open aortic arch surgery after type A dissection repair is challenging. We sought to review our surgical experience to analyse the causes and timing, establish the risk profile for this patient population, and better define outcomes.

METHODS

From 2000 to 2014, we identified 55 patients who required aortic arch surgery after a previous type A dissection repair. Medical records were available for review including computerized tomographic angiograms, cerebral protection strategies and follow-up.

RESULTS

The mean interval from previous type A dissection repair to aortic arch surgery was 5.7 ± 5.4 years. At reoperation 36 patients (65%) had total arch replacement and 19 (35%) had hemiarch replacement. Indications for reoperations were: enlarging aneurysm in 27 (49%), impending rupture in 12 (22%), chronic dissection in 10 (18%) and aneurysms in 6 (11%). Arterial peripheral cannulation was used in 80% of patients. Selective antegrade cerebral perfusion was used in 35 patients (64%) and retrograde perfusion in 2 (4%). There were 3 perioperative deaths (5%) and 4 cases of permanent stroke (7%). Survival rates were 90, 85 and 77% at the 1-, 3- and 5-year follow-up, respectively. The 5-year survival rate was 10% lower than that of an age- and sex-matched population (P < 0.001). The only predictor of the follow-up mortality was older age (odds ratio: 1.07, 95% confidence interval: 1.02-1.13, P = 0.007).

CONCLUSIONS

Aortic arch surgery after previous type A dissection repair can be performed with satisfactory early and mid-term results and acceptable risk of stroke. Cerebral perfusion strategies likely contribute to positive outcomes. Favourable mid-term survival justifies performing such difficult reoperations.

摘要

目的

A型夹层修复术后的主动脉弓开放手术具有挑战性。我们试图回顾我们的手术经验,分析原因和时机,确定该患者群体的风险特征,并更好地界定治疗结果。

方法

2000年至2014年,我们确定了55例在先前A型夹层修复术后需要进行主动脉弓手术的患者。可查阅病历,包括计算机断层血管造影、脑保护策略和随访情况。

结果

从先前A型夹层修复到主动脉弓手术的平均间隔时间为5.7±5.4年。再次手术时,36例(65%)患者进行了全弓置换,19例(35%)患者进行了半弓置换。再次手术的指征为:动脉瘤增大27例(49%),即将破裂12例(22%),慢性夹层10例(18%),动脉瘤6例(11%)。80%的患者采用动脉外周插管。35例(64%)患者采用选择性顺行脑灌注,2例(4%)患者采用逆行灌注。围手术期死亡3例(5%),永久性卒中4例(7%)。1年、3年和5年随访时的生存率分别为90%、85%和77%。5年生存率比年龄和性别匹配人群低10%(P<0.001)。随访死亡率的唯一预测因素是年龄较大(比值比:1.07,95%置信区间:1.02-1.13,P=0.007)。

结论

先前A型夹层修复术后的主动脉弓手术可取得满意的早期和中期结果,且卒中风险可接受。脑灌注策略可能有助于取得良好的治疗结果。良好的中期生存率证明进行此类困难的再次手术是合理的。

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