Becker I, Roggendorf W
Institute of Brain Research, University of Tübingen, F.R.G.
J Neuroimmunol. 1989 Dec;25(2-3):161-7. doi: 10.1016/0165-5728(89)90133-1.
Using monoclonal antibodies (MAB) in combination with the alkaline phosphatase anti-alkaline phosphatase technique, 20 meningiomas were examined for the expression of major histocompatibility complex (MHC) antigens. Most of the tumor cells were labeled with the MAB for class I MHC antigens. In addition, class I reactivity was seen in the tumor blood vessels, presumably reflecting labeling of the endothelial cells. Tumor cells and endothelium were not labeled with the MAB for class II MHC antigen HLA-DR. Occasionally a staining of periendothelial cells was detected. The presence of MHC antigens supports the assumption that endothelial cells play a role in antigen presentation, perhaps relevant to the initiation of an immune response, and that meningioma cells can be a target of T cell-mediated immune reactions.
利用单克隆抗体（MAB）结合碱性磷酸酶抗碱性磷酸酶技术，对20例脑膜瘤进行了主要组织相容性复合体（MHC）抗原表达检测。大多数肿瘤细胞被用于I类MHC抗原的MAB标记。此外，在肿瘤血管中可见I类反应性，推测这反映了内皮细胞的标记情况。肿瘤细胞和内皮细胞未被用于II类MHC抗原HLA-DR的MAB标记。偶尔可检测到血管周细胞染色。MHC抗原的存在支持了这样一种假设，即内皮细胞在抗原呈递中起作用，这可能与免疫反应的启动有关，并且脑膜瘤细胞可能是T细胞介导的免疫反应的靶标。
