Viktorsson Elvar Ørn, Åstrand Ove Alexander Høgmoen, Haseeb Rasha Sabah, Görbitz Carl Henrik, Rongved Pål
School of Pharmacy, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway.
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N-0315 Oslo, Norway.
Acta Crystallogr E Crystallogr Commun. 2015 Feb 18;71(Pt 3):275-7. doi: 10.1107/S2056989015001747. eCollection 2015 Mar 1.
The literature compound 3β-hy-droxy-bis-nor-5-cholenic aldehyde is an important inter-mediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As part of our ongoing search for new LXR antagonists, the title compound, C24H39NO3, has proven to be an important inter-mediate in our new synthetic pathway, giving the corresponding aldehyde in high yield and in only three steps from the commercially available 3β-hy-droxy-bis-nor-5-cholenic acid. The title amide crystallized with two mol-ecules in the asymmetric unit, linked into helices by O-H⋯O hydrogen bonds involving the hy-droxy and carbonyl groups.
文献报道的化合物3β-羟基双降-5-胆烯醛是合成新型核氧化甾醇受体肝X受体调节剂的重要中间体。作为我们持续寻找新型肝X受体拮抗剂工作的一部分，标题化合物C24H39NO3已被证明是我们新合成路线中的重要中间体，从市售的3β-羟基双降-5-胆烯酸出发，只需三步就能以高产率得到相应的醛。标题酰胺在不对称单元中由两个分子结晶而成，通过涉及羟基和羰基的O-H⋯O氢键连接成螺旋结构。
