Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
Chem Commun (Camb). 2013 Oct 7;49(77):8586-98. doi: 10.1039/c3cc45463k.
This article covers N-acyl chiral auxiliary-based approaches to the asymmetric synthesis of enantiopure aldehydes and ketones. The use of diastereoisomerically pure N-acyl derivatives of chiral auxiliaries (including chiral Weinreb amide equivalents) and their conversion to the corresponding enantiopure aldehydes and ketones in a single synthetic operation by treatment with a hydride reducing agent or an organometallic reagent, respectively, are highlighted.
本文综述了基于 N-酰基手性助剂的对映纯醛和酮的不对称合成方法。通过使用非对映异构体纯的手性助剂的 N-酰基衍生物（包括手性 Weinreb 酰胺等价物），并分别用氢化物还原剂或有机金属试剂处理，将其转化为相应的对映纯醛和酮，这一过程在单个合成操作中完成，是本文的重点。
