Schmidt Michael T, Huang Qin, Alkan Serhan
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Adv Anat Pathol. 2015 May;22(3):168-80. doi: 10.1097/PAP.0000000000000065.
Recent advances in diffuse large B-cell lymphoma are changing the way pathologists approach, diagnose, and report on this heterogeneous group of lymphomas. The purpose of this review is to provide a practical yet comprehensive approach to diffuse large B-cell lymphoma and aggressive B-cell lymphomas that can be used and easily interpreted by pathologists at all levels of training. It will address important concepts and current testing modalities which provide important prognostic information for the clinician when considering appropriate chemotherapeutic regimens for each patient's lymphoma diagnosis. It will also provide some insights into recently reported signaling pathways and molecular alterations and their contribution to lymphomagenesis and how identifying these abnormalities may provide future potential therapeutic targets for these aggressive lymphomas.
弥漫性大B细胞淋巴瘤的最新进展正在改变病理学家处理、诊断和报告这类异质性淋巴瘤的方式。本综述的目的是提供一种实用且全面的方法来处理弥漫性大B细胞淋巴瘤和侵袭性B细胞淋巴瘤，各级培训水平的病理学家都可以使用并轻松解读。它将阐述重要概念和当前的检测方法，这些方法在临床医生为每位患者的淋巴瘤诊断考虑合适的化疗方案时，可为其提供重要的预后信息。它还将对最近报道的信号通路和分子改变及其对淋巴瘤发生的作用提供一些见解，以及识别这些异常如何可能为这些侵袭性淋巴瘤提供未来潜在的治疗靶点。
