Xiao M-L, Liu J-Q, Chen C
Mol Biol (Mosk). 2014 Nov-Dec;48(6):963-9. doi: 10.7868/s0026898414060202.
Accumulating evidence suggests that proinflammatory cytokines play an important role in white matter injury in preterm infants, a condition in which oligodendrocyte (OL) progenitor cells are preferentially injured. We investigated the role of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its death (TRAIL-R1, TRAIL-R2) and decoy (TRAIL-R3, TRAIL-R4) receptors in periventricular white matter injury (PWMI). We hypothesized that the maturation-dependent vulnerability of OLs to TRAIL is due to differential TRAIL receptor expression. We previously investigated TRAIL/TRAIL receptor expression levels in rat OLs in vivo in the context of PWMI. We found that during different developmental stages, human OLs differentially express TRAIL receptors; there is a progressive loss of sensitivity to TRAIL as OLs proceed through the maturation process. Our results show that both TRAIL-R1 and -R2 are highly expressed on human OL progenitors and pre-OLs, while TRAIL-R3 and TRAIL-R4 are mainly expressed on immature and mature human OLs. Our results suggest that TRAIL-R1 and TRAIL-R2 might mediate the death signal in human OL precursor cells and pre-OLs.
越来越多的证据表明，促炎细胞因子在早产儿白质损伤中起重要作用，在这种情况下少突胶质细胞（OL）祖细胞优先受损。我们研究了肿瘤坏死因子（TNF）相关凋亡诱导配体（TRAIL）及其死亡受体（TRAIL-R1、TRAIL-R2）和诱饵受体（TRAIL-R3、TRAIL-R4）在脑室周围白质损伤（PWMI）中的作用。我们假设OL对TRAIL的成熟依赖性易感性是由于TRAIL受体表达的差异。我们之前在PWMI的背景下研究了大鼠OL体内TRAIL/TRAIL受体的表达水平。我们发现，在不同的发育阶段，人类OL差异表达TRAIL受体；随着OL经历成熟过程，对TRAIL的敏感性逐渐丧失。我们的结果表明，TRAIL-R1和TRAIL-R2在人类OL祖细胞和前少突胶质细胞上高表达，而TRAIL-R3和TRAIL-R4主要在未成熟和成熟的人类OL上表达。我们的结果表明，TRAIL-R1和TRAIL-R2可能介导人类OL前体细胞和前少突胶质细胞中的死亡信号。
