Kumar S, Deb R, Singh U, Ganguly I, Mandal D K, Tyagi S, Kumar M, Sengar G, Sharma S, Singh R, Singh R
Indian Council of Agricultural Research- Central Institute for Research on Cattle, Meerut, India.
Reprod Domest Anim. 2015 Jun;50(3):505-9. doi: 10.1111/rda.12522. Epub 2015 Apr 6.
Mammalian circadian locomotor output cycles kaput (CLOCK) gene encodes a transcription factor that affects both the persistence and the period of circadian rhythms. Earlier reports suggested that CLOCK gene might be associated with male infertility in human. Present investigation, for the first time, reports that CLOCK gene expresses differentially between good and poor quality crossbred bull semen. The relative expression of CLOCK was significantly (p < 0.05) higher among good quality bull semen than motility-impaired ones. Clusterins (CLU) are series of genes associated with a variety of physiological activities including spermatogenesis, apoptosis and degenerative disease conditions. In the present context, we also investigated that the expression of CLU gene was significantly (p < 0.05) higher among motility-impaired crossbred bull semen compared to the good quality one.
哺乳动物昼夜节律运动输出周期基因（CLOCK）编码一种转录因子，它会影响昼夜节律的持续性和周期。早期报告表明，CLOCK基因可能与人类男性不育有关。目前的研究首次报告，CLOCK基因在优质和劣质杂交公牛精液中的表达存在差异。优质公牛精液中CLOCK的相对表达显著高于活力受损的精液（p < 0.05）。簇集素（CLU）是一系列与多种生理活动相关的基因，包括精子发生、细胞凋亡和退行性疾病状况。在当前背景下，我们还研究发现，与优质杂交公牛精液相比，活力受损的杂交公牛精液中CLU基因的表达显著更高（p < 0.05）。
