Departement Chemie und Angewandte Biowissenschaften, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich (Switzerland).
Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5171-4. doi: 10.1002/anie.201501807. Epub 2015 Apr 2.
Bis(isonitrile) iron(II) complexes bearing a C2 -symmetric diamino (NH)2 P2 macrocyclic ligand efficiently catalyze the hydrogenation of polar bonds of a broad scope of substrates (ketones, enones, and imines) in high yield (up to 99.5 %), excellent enantioselectivity (up to 99 % ee), and with low catalyst loading (generally 0.1 mol %). The catalyst can be easily tuned by modifying the substituents of the isonitrile ligand.
具有 C2 对称二氨基（NH）2 P2 大环配体的双（异腈）铁（II）配合物能够高效地催化多种底物（酮、烯酮和亚胺）的极性键的氢化反应，产率高（高达 99.5%），对映选择性好（高达 99%ee），催化剂用量低（通常为 0.1 mol%）。通过修饰异腈配体的取代基，可以很容易地调整催化剂。
