Passera Alessandro, Mezzetti Antonio
Departement Chemie und Angewandte Biowissenschaften, Eidgenössische Technische Hochschule (ETH) Zürich, 8093, Zürich, Switzerland.
Angew Chem Int Ed Engl. 2020 Jan 2;59(1):187-191. doi: 10.1002/anie.201912605. Epub 2019 Nov 29.
The bis(carbonyl) manganese(I) complex [Mn(CO) (1)]Br (2) with a chiral (NH) P macrocyclic ligand (1) catalyzes the asymmetric transfer hydrogenation of polar double bonds with 2-propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcohols in high yields (up to >99 %) and with excellent enantioselectivities (90-99 % ee). A stereochemical model based on attractive CH-π interactions is proposed.
具有手性(NH)P大环配体(1)的双(羰基)锰(I)配合物[Mn(CO)(1)]Br(2)以2-丙醇为氢源催化极性双键的不对称转移氢化反应。酮类化合物(43种底物)以高产率(高达>99%)和优异的对映选择性(90-99%ee)被还原为醇。提出了一种基于有吸引力的CH-π相互作用的立体化学模型。
