秀丽隐杆线虫的运动：小回路，大功能。

C. elegans locomotion: small circuits, complex functions.

机构信息

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; Department of Physiology, University of Toronto, Toronto, ON, Canada M5S 1A8.

Center for Brain Science, Department of Physics, Harvard University, Cambridge, MA 02138, United States.

出版信息

Curr Opin Neurobiol. 2015 Aug;33:117-26. doi: 10.1016/j.conb.2015.03.009. Epub 2015 Apr 4.

DOI:10.1016/j.conb.2015.03.009

PMID:25845627

Abstract

With 302 neurons in the adult Caenorhabditis elegans nervous system, it should be possible to build models of complex behaviors spanning sensory input to motor output. The logic of the motor circuit is an essential component of such models. Advances in physiological, anatomical, and neurogenetic analysis are revealing a surprisingly complex signaling network in the worm's small motor circuit. We are progressing towards a systems level dissection of the network of premotor interneurons, motor neurons, and muscle cells that move the animal forward and backward in its environment.

摘要

在成年秀丽隐杆线虫的神经系统中，有 302 个神经元，应该有可能建立从感觉输入到运动输出的复杂行为模型。运动回路的逻辑是此类模型的重要组成部分。在生理、解剖和神经遗传学分析方面的进展揭示了线虫小运动回路中一个令人惊讶的复杂信号网络。我们正在朝着对控制动物在环境中前后移动的前置运动神经元、运动神经元和肌肉细胞的网络进行系统水平剖析的方向前进。