Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Dermatology, Haukeland University Hospital, Bergen, Norway.
J Eur Acad Dermatol Venereol. 2015 Nov;29(11):2128-35. doi: 10.1111/jdv.13151. Epub 2015 Apr 6.
Renal transplant recipients (RTR) have an increased risk of developing cutaneous squamous cell carcinomas (SCC). These SCC are often more aggressive than SCC in immunocompetent individuals.
In this comparative study, we analysed the cell composition in the tissue immediately surrounding invasive SCC in immunosuppressed RTR and immunocompetent controls in an effort to further elucidate the role of the local immune system.
Morphology and quantity of various dendritic cell (DC) subsets, macrophages and FoxP3+ T cells were analysed by immunohistochemical staining.
The number of CD11c+ myeloid DC and FoxP3+ T cells was significantly reduced in RTR, whereas the number of plasmacytoid DC, Langerhans cells and macrophages was similar in RTR and controls.
A reduction in CD11c+ mDC in peritumoral dermis in RTR might contribute to impaired immunosurveillance thus giving rise to an increased risk to develop aggressive SCC in these patients.
肾移植受者（RTR）发生皮肤鳞状细胞癌（SCC）的风险增加。这些 SCC 通常比免疫功能正常个体中的 SCC 更具侵袭性。
在这项比较研究中，我们分析了免疫抑制的 RTR 和免疫功能正常对照者侵袭性 SCC 周围组织中的细胞组成，以进一步阐明局部免疫系统的作用。
通过免疫组织化学染色分析各种树突状细胞（DC）亚群、巨噬细胞和 FoxP3+T 细胞的形态和数量。
RTR 中 CD11c+髓样 DC 和 FoxP3+T 细胞的数量显著减少，而 RTR 和对照组中浆细胞样 DC、朗格汉斯细胞和巨噬细胞的数量相似。
RTR 肿瘤周围真皮中 CD11c+mDC 的减少可能导致免疫监视受损，从而导致这些患者发生侵袭性 SCC 的风险增加。
