Hodgson Susan, Lurz Peter W W, Shirley Mark D F, Bythell Mary, Rankin Judith
MRC-PHE Centre for Environment & Health, Department of Epidemiology & Biostatistics, Imperial College London, United Kingdom; Institute of Health & Society, Newcastle University, Newcastle upon Tyne, United Kingdom.
School of Biology, Newcastle University, Newcastle upon Tyne, United Kingdom; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
Int J Hyg Environ Health. 2015 Jun;218(4):414-21. doi: 10.1016/j.ijheh.2015.03.007. Epub 2015 Mar 25.
Pregnant women are a highly mobile group, yet studies suggest exposure error due to migration in pregnancy is minimal. We aimed to investigate the impact of maternal residential mobility on exposure to environmental variables (urban fabric, roads and air pollution (PM10 and NO₂)) and socio-economic factors (deprivation) that varied spatially and temporally.
We used data on residential histories for deliveries at ≥ 24 weeks gestation recorded by the Northern Congenital Abnormality Survey, 2000-2008 (n=5399) to compare: (a) exposure at conception assigned to maternal postcode at delivery versus maternal postcode at conception, and (b) exposure at conception assigned to maternal postcode at delivery versus mean exposure based on residences throughout pregnancy.
In this population, 24.4% of women moved during pregnancy. Depending on the exposure variable assessed, 1-12% of women overall were assigned an exposure at delivery >1 SD different to that at conception, and 2-25% assigned an exposure at delivery >1 SD different to the mean exposure throughout pregnancy.
To meaningfully explore the subtle associations between environmental exposures and health, consideration must be given to error introduced by residential mobility.
孕妇是一个流动性很强的群体，但研究表明孕期迁移导致的暴露误差极小。我们旨在调查孕产妇居住流动性对暴露于空间和时间上变化的环境变量（城市结构、道路和空气污染（PM10和NO₂））以及社会经济因素（贫困）的影响。
我们使用了2000 - 2008年北方先天性异常调查记录的≥24周妊娠分娩的居住史数据（n = 5399），以比较：（a）分娩时根据母亲邮政编码分配的受孕时暴露情况与受孕时母亲邮政编码对应的暴露情况，以及（b）分娩时根据母亲邮政编码分配的受孕时暴露情况与基于整个孕期居住地的平均暴露情况。
在该人群中，24.4%的女性在孕期迁移。根据评估的暴露变量不同，总体上1 - 12%的女性分娩时分配的暴露情况与受孕时相差>1个标准差，2 - 25%的女性分娩时分配的暴露情况与整个孕期的平均暴露情况相差>1个标准差。
为了有意义地探索环境暴露与健康之间的细微关联，必须考虑居住流动性引入的误差。
