El Aidy Sahar, Dinan Timothy G, Cryan John F
Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Egypt.
Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Psychiatry, University College Cork, Cork, Ireland.
Clin Ther. 2015 May 1;37(5):954-67. doi: 10.1016/j.clinthera.2015.03.002. Epub 2015 Apr 3.
It is well established that mammals are so-called super-organisms that coexist with a complex microbiota. Growing evidence points to the delicacy of this host-microbe interplay and how disruptive interventions could have lifelong consequences. The goal of this article was to provide insights into the potential role of the gut microbiota in coordinating the immune-neuroendocrine cross-talk.
Literature from a range of sources, including PubMed, Google Scholar, and MEDLINE, was searched to identify recent reports regarding the impact of the gut microbiota on the host immune and neuroendocrine systems in health and disease.
The immune system and nervous system are in continuous communication to maintain a state of homeostasis. Significant gaps in knowledge remain regarding the effect of the gut microbiota in coordinating the immune-nervous systems dialogue. Recent evidence from experimental animal models found that stimulation of subsets of immune cells by the gut microbiota, and the subsequent cross-talk between the immune cells and enteric neurons, may have a major impact on the host in health and disease.
Data from rodent models, as well as from a few human studies, suggest that the gut microbiota may have a major role in coordinating the communication between the immune and neuroendocrine systems to develop and maintain homeostasis. However, the underlying mechanisms remain unclear. The challenge now is to fully decipher the molecular mechanisms that link the gut microbiota, the immune system, and the neuroendocrine system in a network of communication to eventually translate these findings to the human situation, both in health and disease.
哺乳动物是与复杂微生物群共存的所谓超级生物体，这一点已得到充分证实。越来越多的证据表明这种宿主与微生物之间相互作用的微妙性，以及干扰性干预如何可能产生终身影响。本文的目的是深入探讨肠道微生物群在协调免疫 - 神经内分泌相互作用中的潜在作用。
检索了包括PubMed、谷歌学术和MEDLINE在内的一系列来源的文献，以确定关于肠道微生物群在健康和疾病中对宿主免疫和神经内分泌系统影响的最新报告。
免疫系统和神经系统持续相互沟通以维持内稳态。关于肠道微生物群在协调免疫 - 神经系统对话中的作用，仍存在重大知识空白。来自实验动物模型的最新证据发现，肠道微生物群对免疫细胞亚群的刺激，以及随后免疫细胞与肠神经元之间的相互作用，可能对健康和疾病状态下的宿主产生重大影响。
来自啮齿动物模型以及一些人体研究的数据表明，肠道微生物群可能在协调免疫和神经内分泌系统之间的沟通以建立和维持内稳态方面发挥主要作用。然而，其潜在机制仍不清楚。目前的挑战是全面破译在一个沟通网络中将肠道微生物群、免疫系统和神经内分泌系统联系起来的分子机制，最终将这些发现转化到人类健康和疾病的实际情况中。
Zotero 插件