Gulas Ewelina, Wysiadecki Grzegorz, Strzelecki Dominik, Gawlik-Kotelnicka Oliwia, Polguj Michał
Zakład Angiologii Uniwersytetu Medycznego w Łodzi.
Zakład Anatomii Prawidłowej i Klinicznej Uniwersytetu Medycznego w Łodzi.
Psychiatr Pol. 2018 Dec 29;52(6):1023-1039. doi: 10.12740/PP/OnlineFirst/81103.
Every single human consists of thousands of genes, billions of neurons and trillions of bacteria. There is a rapidly growing number of data that links the gut microbiome to the development and functioning of the central nervous system, which is a currently proposed paradigm shift in neuroscience. Knowledge on the relationship between gut microbiota and mental disorders is constantly increasing. This phenomenon is known as "gut-brain axis". The strongest evidence for the role of microbes in the gut-brain axis comes from animal studies. Nevertheless, the gutbrain crosstalk is a bidirectional communication system that not only provides gastrointestinal homeostasis, but can also affect motivation as well as higher cognitive functions. Moreover, gut microbiome can be associated with obesity and inflammatory gastrointestinal disorders. According to the recent studies, there is a link between the composition of gut microbiota and mental disorders in animals (response to depression and chronic stress). This subject requires further examination, especially taking into consideration potential therapeutic options.
每个人都由数以千计的基因、数十亿的神经元和数万亿的细菌组成。越来越多的数据将肠道微生物群与中枢神经系统的发育和功能联系起来，这是目前神经科学中提出的一种范式转变。关于肠道微生物群与精神障碍之间关系的知识正在不断增加。这种现象被称为“肠-脑轴”。微生物在肠-脑轴中作用的最有力证据来自动物研究。然而，肠-脑相互作用是一个双向通信系统，它不仅能维持胃肠道内环境稳定，还会影响动机以及更高层次的认知功能。此外，肠道微生物群可能与肥胖和炎症性胃肠道疾病有关。根据最近的研究，动物肠道微生物群的组成与精神障碍之间存在联系（对抑郁和慢性应激的反应）。这个问题需要进一步研究，特别是考虑到潜在的治疗选择。
