Podnar Simon
Institute of Clinical Neurophysiology, Division of Neurology, University Medical Centre Ljubljana, SI-1525, Ljubljana, Slovenia.
Muscle Nerve. 2015 Dec;52(6):986-92. doi: 10.1002/mus.24673. Epub 2015 Oct 10.
Phrenic neuropathies (PNs) are a major cause of dyspnea, orthopnea, and hypercapnic respiratory failure. The aim of the study was to obtain diagnostic findings, assess therapeutic options, and review outcomes in PN patients.
From 2004 to 2013, patients with PN referred to the author's institution were studied using clinical, pulmonary function, and electrodiagnostic tests. A PubMed search of published PN reports was also done. Unilateral PN (UPN) and bilateral PN (BPN) patients were compared.
The analysis consisted of 10 UPN and 9 BPN patients seen by the author, plus previous reports of 18 UPN and 40 BPN patients. BPN patients were older (in the author's series) and were more often hypertensive. They reported pain less often, dyspnea and orthopnea more often, and had worse results on pulmonary function tests than UPN patients.
UPN and BPN are probably 2 variants of the same, immune-mediated focal neuropathy. Electrodiagnosis is a valuable confirmatory test for PN.
膈神经病变（PNs）是导致呼吸困难、端坐呼吸和高碳酸血症性呼吸衰竭的主要原因。本研究的目的是获取诊断结果，评估治疗方案，并回顾PN患者的治疗结果。
2004年至2013年期间，对转诊至作者所在机构的PN患者进行了临床、肺功能和电诊断测试研究。还对PubMed上发表的PN报告进行了检索。对单侧PN（UPN）和双侧PN（BPN）患者进行了比较。
分析包括作者诊治的10例UPN患者和9例BPN患者，以及之前报道的18例UPN患者和40例BPN患者。BPN患者年龄较大（在作者的系列研究中），高血压更为常见。与UPN患者相比，他们较少报告疼痛，更多报告呼吸困难和端坐呼吸，肺功能测试结果更差。
UPN和BPN可能是同一免疫介导的局灶性神经病的两种变体。电诊断是PN的一项有价值的确诊检查。
