Kuşkonmaz Bariş, Uçkan Duygu, Yalnizoğlu Dilek, Günel Mintaze, Karli Oğuz Kader, Konuşkan Bahadir, Anlar Banu
Division of Bone Marrow Transplantation, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Dev Med Child Neurol. 2015 Sep;57(9):880-3. doi: 10.1111/dmcn.12747. Epub 2015 Apr 6.
Subacute sclerosing panencephalitis (SSPE) is a serious, often fatal disease that responds poorly to current treatment modalities. Recently, the ability of mesenchymal stem cells (MSCs) to produce neurotrophic factors and inflammatory molecules has placed them among potential treatment agents for neurological conditions. We report the results of four patients treated with MSC for SSPE. The patients were followed up clinically, and by periodical laboratory evaluations, magnetic resonance imaging (MRI), and electroencephalography. One patient deteriorated to stage III of the disease, two patients remained in the same stage, and one died from disease progression and respiratory problems. Neurological findings and electroencephalography scores were consistent with the clinical course of the patient whereas MRI showed new inflammatory lesions in two patients. This is the first report of the application of MSC in SSPE. No benefit is demonstrated.
亚急性硬化性全脑炎（SSPE）是一种严重的、通常致命的疾病，对目前的治疗方式反应不佳。最近，间充质干细胞（MSCs）产生神经营养因子和炎症分子的能力使其成为神经系统疾病潜在的治疗药物之一。我们报告了4例接受间充质干细胞治疗亚急性硬化性全脑炎的患者的结果。对患者进行了临床随访，并通过定期实验室评估、磁共振成像（MRI）和脑电图检查。1例患者病情恶化为疾病III期，2例患者病情维持在同一阶段，1例患者因疾病进展和呼吸问题死亡。神经学检查结果和脑电图评分与患者的临床病程一致，而MRI显示2例患者出现新的炎性病变。这是间充质干细胞应用于亚急性硬化性全脑炎的首次报告。未显示出益处。
