Is cholesterol good or bad for your brain?--NMDARs have a say.
作者信息
Wollmuth Lonnie P
机构信息
Department of Neurobiology and Behaviour and Centre for Nervous System Disorders, Stony Brook University, Stony Brook, NY, USA.
出版信息
J Physiol. 2015 May 15;593(10):2251-2. doi: 10.1113/JP270325. Epub 2015 Apr 2.
Abstract
摘要
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本文引用的文献
1
Cholesterol modulates open probability and desensitization of NMDA receptors.胆固醇调节N-甲基-D-天冬氨酸受体的开放概率和脱敏作用。
J Physiol. 2015 May 15;593(10):2279-93. doi: 10.1113/jphysiol.2014.288209. Epub 2015 Mar 24.
2
Lipid modulation of ion channels through specific binding sites.通过特定结合位点对离子通道进行脂质调节。
Biochim Biophys Acta. 2014 Jun;1838(6):1560-7. doi: 10.1016/j.bbamem.2013.10.023. Epub 2013 Nov 8.
3
Neuroprotection by lowering cholesterol: a decrease in membrane cholesterol content reduces transporter-mediated glutamate release from brain nerve terminals.通过降低胆固醇实现神经保护：膜胆固醇含量的降低减少了转运体介导的谷氨酸从脑神经末梢的释放。
Biochim Biophys Acta. 2012 Oct;1822(10):1553-61. doi: 10.1016/j.bbadis.2012.06.005. Epub 2012 Jun 17.
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Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia.精神分裂症中的皮质苍白球中间神经元与认知功能障碍。
Trends Neurosci. 2012 Jan;35(1):57-67. doi: 10.1016/j.tins.2011.10.004. Epub 2011 Dec 6.
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Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs.两亲性药物通过脂质双层对离子通道功能的调节
J Gen Physiol. 2008 May;131(5):421-9. doi: 10.1085/jgp.200709948. Epub 2008 Apr 14.
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Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch.脂质体的重构以及膜拉伸对重组N-甲基-D-天冬氨酸受体通道的调节作用。
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1540-5. doi: 10.1073/pnas.0609649104. Epub 2007 Jan 22.
7
NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons.小脑颗粒神经元自突触处的NMDA受体亚型
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