Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Curr Opin Virol. 2015 Aug;13:11-6. doi: 10.1016/j.coviro.2015.03.010. Epub 2015 Apr 2.
Oncolytic viruses selectively replicate in tumor cells and elicit antitumor effects in vivo by both direct and indirect methods. They are attractive avenues of cancer therapy due to the absence of toxic side effects often seen in current treatment modalities. Bovine herpesvirus type 1 (BHV-1) holds promise as a broad-spectrum oncolytic vector that is able to infect and kill human tumor cells from a variety of histological origins, including cancer-initiating cells. In the majority of cases, BHV-1 elicits tumor cell death in the absence of a productive infection. In vivo, BHV-1 affects the incidence of secondary lesions in cotton rats bearing subcutaneous breast adenocarcinomas. These recent studies contribute to the characterization of BHV-1 as an oncolytic virus.
溶瘤病毒通过直接和间接方法选择性地在肿瘤细胞中复制，并在体内引发抗肿瘤作用。由于目前的治疗方式常常会产生毒性副作用，因此它们成为癌症治疗的一个有吸引力的途径。牛疱疹病毒 1 型（BHV-1）有望成为一种广谱溶瘤载体，能够感染和杀死来自多种组织来源的人类肿瘤细胞，包括癌症起始细胞。在大多数情况下，BHV-1 在没有产生感染的情况下引发肿瘤细胞死亡。在体内，BHV-1 影响携带皮下乳腺腺癌的棉鼠中继发性病变的发生率。这些最近的研究有助于将 BHV-1 表征为一种溶瘤病毒。
