Eom Yong Hwa, Kim Eun Jin, Chae Byung Joo, Song Byung Joo, Jung Sang Seol
Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Surg Oncol. 2015 Jun;111(7):824-8. doi: 10.1002/jso.23898. Epub 2015 Apr 6.
More superficially located tumors may be more likely than deeper tumors to metastasize to the axillary nodes via the lymphatics. The aim of this study was to determine whether breast cancer distance from the skin affects axillary node metastasis, ipsilateral breast cancer recurrence, or recurrence-free survival.
A total of 1,005 consecutive patients with breast cancer who underwent surgery between January 2003 and December 2009 were selected. The distance of the tumor from the skin was measured from the skin to the most anterior hypoechoic leading edge of the lesion.
In total, 603 (68%) patients had no axillary nodal metastasis, and 288 (32%) had axillary nodal metastasis. A breast cancer distance from the skin <3 mm induced more axillary nodal metastasis (P = 0.039). However, no significant correlation was observed between breast cancer distance from the skin <3 mm and ipsilateral breast cancer recurrence (P = 0.788) or recurrence-free survival (P = 0.353).
Breast cancers located closer to the skin had a higher incidence of axillary nodal metastasis. Therefore, tumor distance from the skin should be considered when evaluating a patient with breast cancer and considering the risk of nodal metastasis.
相较于位置较深的肿瘤，位置较浅的肿瘤可能更易通过淋巴管转移至腋窝淋巴结。本研究旨在确定乳腺癌距皮肤的距离是否会影响腋窝淋巴结转移、同侧乳腺癌复发或无复发生存率。
选取2003年1月至2009年12月期间连续接受手术的1005例乳腺癌患者。测量肿瘤距皮肤的距离，即从皮肤至病变最前端低回声前缘的距离。
总计603例（68%）患者无腋窝淋巴结转移，288例（32%）有腋窝淋巴结转移。距皮肤距离<3 mm的乳腺癌导致更多腋窝淋巴结转移（P = 0.039）。然而，距皮肤距离<3 mm的乳腺癌与同侧乳腺癌复发（P = 0.788）或无复发生存率（P = 0.353）之间未观察到显著相关性。
位置更靠近皮肤的乳腺癌腋窝淋巴结转移发生率更高。因此，在评估乳腺癌患者并考虑淋巴结转移风险时，应考虑肿瘤距皮肤的距离。
