Piéroni Laurence, Cristol Jean-Paul
Laboratoire de biologie médicale, Centre hospitalier d'Avignon, Avignon, France.
Service de biochimie, CHU Lapeyronie, Montpellier, France.
Ann Biol Clin (Paris). 2015 Mar-Apr;73(2):151-7. doi: 10.1684/abc.2015.1029.
The early diagnosis of chronic kidney disease (CKD) is based on the detection of markers of renal damage in urine collection. These urinary bio-markers are measurable before the appearance of functional defect, which is diagnosed with a decrease of glomerular filtration rate. Albuminuria, preferentially expressed as urinary albumin/creatinin ratio, is one of the marker of CKD. But today, other urinary biomarkers, monitoring tubulointersticial damage, are of interest in early diagnosis of CKD. In acute kidney injury, these markers could improve diagnostic tests, since they increase faster than serum creatinin. We propose a review of the urinary biomarkers of renal dysfunction used in routine clinical practice in 2015.
慢性肾脏病（CKD）的早期诊断基于对尿液中肾脏损伤标志物的检测。这些尿液生物标志物在功能性缺陷出现之前即可检测到，功能性缺陷是通过肾小球滤过率降低来诊断的。蛋白尿，优先表示为尿白蛋白/肌酐比值，是CKD的标志物之一。但如今，其他监测肾小管间质损伤的尿液生物标志物在CKD的早期诊断中受到关注。在急性肾损伤中，这些标志物可改善诊断测试，因为它们比血清肌酐升高得更快。我们对2015年常规临床实践中使用的肾功能障碍尿液生物标志物进行综述。
