除了急性肾衰竭病例外，肾小球和肾小管功能的尿液标志物在临床实践中有用吗？

Aside from acute renal failure cases, are urinary markers of glomerular and tubular function useful in clinical practice?

作者信息

Bastard Jean-Philippe, Fellahi Soraya, Regeniter Axel, Capeau Jacqueline, Ronco Pierre, Plaisier Emmanuelle

机构信息

AP-HP, UF Biomarqueurs Inflammatoires et Métaboliques, Service de Biochimie et Hormonologie, Hôpital Tenon, Paris, France; Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_938, CDR-Saint-Antoine, DHU i2B, IHU ICAN, Paris, France.

出版信息

Clin Biochem. 2019 Mar;65:1-6. doi: 10.1016/j.clinbiochem.2019.01.006. Epub 2019 Jan 25.

DOI:10.1016/j.clinbiochem.2019.01.006

PMID:30685208

Abstract

The qualitative evaluation of proteinuria represents a crucial diagnostic step in clinical practice for the classification of renal diseases according to glomerular, tubulo-interstitial, mixed injury or related to monoclonal gammopathy. Combined with the quantitative evaluation, it also allows an assessment of the disease's severity and prognosis as well as the response to treatment. The development of the urine protein profile (UPP) combines specific urine protein assays on a urine spot analyzing glomerular protein markers such as albumin, transferrin and immunoglobulin G, and tubular markers such as alpha-1microglobulin and retinol binding protein, to generate a detailed quantitative and qualitative proteinuria assessment. This short overview proposes to illustrate the diagnostic and prognostic usefulness of UPP in different common clinical situations.

摘要

蛋白尿的定性评估是临床实践中根据肾小球、肾小管间质、混合性损伤或与单克隆丙种球蛋白病相关对肾脏疾病进行分类的关键诊断步骤。结合定量评估，它还可以评估疾病的严重程度和预后以及对治疗的反应。尿蛋白谱（UPP）的发展结合了对尿样进行特定的尿蛋白检测，分析肾小球蛋白标志物如白蛋白、转铁蛋白和免疫球蛋白G，以及肾小管标志物如α-1微球蛋白和视黄醇结合蛋白，以生成详细的定量和定性蛋白尿评估。本简短概述旨在说明UPP在不同常见临床情况下的诊断和预后用途。