Marumoto Y, Kaibara M, Murata T
Department of Obstetrics and Gynecology, Doai Memorial Hospital, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Sep;41(9):1380-6.
It has been reported that preeclampsia and pregnancy resulting in intrauterine growth retardation (IUGR) are associated with high hematocrits. The relations between hematocrits (Ht) and platelet volumes in normal and abnormal pregnancies were investigated to clarify a hemorheological effect on formation of microthrombus. 1) In normal pregnancy, Ht was decreased from 12-19 weeks gestation and reached its lowest level at 28-31 weeks gestation. The mean platelet volume (MPV) was decreased from 20 to 31 weeks gestation but markedly increased from 38 to 41 weeks gestation. The platelet count (Pl) remained unchanged during pregnancy. 2) In severe type of preeclampsia, at 28-37 weeks gestation Ht and MPV were markedly increased and Pl was markedly decreased at 38-41 weeks gestation as compared with normal pregnancies. 3) Mothers who delivered IUGR had a much higher level of Ht at 28-35 weeks gestation and MPV level from 38 weeks gestation than in normal mothers. As the volume of young platelets is large, increased MPV is suggestive of the occurrence of platelet consumption. From these results, it was suggested that microcirculatory disturbances such as higher blood viscosity due to hemoconcentration and microthrombus formation were related to the onset of preeclampsia or IUGR.
据报道，先兆子痫和导致胎儿宫内生长受限（IUGR）的妊娠与高血细胞比容有关。研究了正常和异常妊娠中血细胞比容（Ht）与血小板体积之间的关系，以阐明血液流变学对微血栓形成的影响。1）在正常妊娠中，血细胞比容从妊娠12 - 19周开始下降，在妊娠28 - 31周达到最低水平。平均血小板体积（MPV）从妊娠20周降至31周，但在妊娠38 - 41周显著增加。血小板计数（Pl）在孕期保持不变。2）在重度先兆子痫中，与正常妊娠相比，妊娠28 - 37周时血细胞比容和平均血小板体积显著增加，妊娠38 - 41周时血小板计数显著降低。3）分娩出宫内生长受限胎儿的母亲在妊娠28 - 35周时血细胞比容水平高得多，在妊娠38周后的平均血小板体积水平高于正常母亲。由于年轻血小板体积大，平均血小板体积增加提示血小板消耗的发生。从这些结果来看，提示诸如血液浓缩导致的血液粘度升高和微血栓形成等微循环障碍与先兆子痫或宫内生长受限的发病有关。
