Akyol Esra Soydaş, Albayrak Yakup, Beyazyüz Murat, Aksoy Nurkan, Kuloglu Murat, Hashimoto Kenji
Deparment of Psychiatry, Yenimahalle Education and Research Hospital, Ankara, Turkey.
Department of Psychiatry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
Neuropsychiatr Dis Treat. 2015 Mar 30;11:865-72. doi: 10.2147/NDT.S79444. eCollection 2015.
Brain-derived neurotrophic factor (BDNF) is a well-established neurotrophin that plays a role in the pathophysiology of numerous psychiatric disorders. Many studies have investigated the serum BDNF levels in patients with schizophrenia. However, there are restricted data in the literature that compare the serum BDNF levels in patients with deficit and nondeficit syndromes. In this study, we aimed to compare the serum BDNF levels between schizophrenic patients with deficit or nondeficit syndrome and healthy controls.
After fulfilling the inclusion and exclusion criteria, 58 patients with schizophrenia and 36 healthy controls were included in the study. The patients were grouped as deficit syndrome (N=23) and nondeficit syndrome (N=35) according to the Schedule for the Deficit Syndrome. Three groups were compared in terms of the sociodemographic and clinical variants and serum BDNF levels.
The groups were similar in terms of age, sex, body mass index, and smoking status. The serum BDNF levels in patients with deficit syndrome were significantly lower than those in healthy controls. In contrast, the serum BDNF levels in patients with nondeficit syndrome were similar to those in healthy controls.
This study suggests that decreased BDNF levels may play a role in the pathophysiology of schizophrenic patients with deficit syndrome. Nonetheless, additional studies using a larger patient sample size are needed to investigate the serum BDNF levels in schizophrenic patients with deficit syndrome.
脑源性神经营养因子（BDNF）是一种公认的神经营养因子，在多种精神疾病的病理生理学中发挥作用。许多研究调查了精神分裂症患者的血清BDNF水平。然而，文献中比较有缺陷和无缺陷综合征患者血清BDNF水平的数据有限。在本研究中，我们旨在比较有缺陷或无缺陷综合征的精神分裂症患者与健康对照者的血清BDNF水平。
在满足纳入和排除标准后，58例精神分裂症患者和36例健康对照者被纳入研究。根据缺陷综合征量表，将患者分为缺陷综合征组（N = 23）和无缺陷综合征组（N = 35）。比较三组在社会人口统计学和临床变量以及血清BDNF水平方面的差异。
三组在年龄、性别、体重指数和吸烟状况方面相似。缺陷综合征患者的血清BDNF水平显著低于健康对照者。相比之下，无缺陷综合征患者的血清BDNF水平与健康对照者相似。
本研究表明，BDNF水平降低可能在有缺陷综合征的精神分裂症患者的病理生理学中起作用。尽管如此，仍需要使用更大样本量的患者进行进一步研究，以调查有缺陷综合征的精神分裂症患者的血清BDNF水平。
