Chakraborty Rajshekhar, Mukkamalla Shiva Kumar Reddy, Gutzmore Garfield, Chan Hon Cheung
Hospitalist Services, Essentia Health, Brainerd, MN, USA.
Department of Internal Medicine, Queens Hospital Center (Affiliated Icahn School of Medicine at Mount Sinai), Jamaica, NY, USA.
J Blood Med. 2015 Mar 23;6:93-7. doi: 10.2147/JBM.S67664. eCollection 2015.
Hodgkin's lymphoma (HL) originates from clonal B cells and is the most common malignancy in the second decade of life. Liver involvement is uncommon at presentation in patients with HL and there is a paucity of data for treatment of patients with severely impaired liver function. We present an unusual case of HL with severe hepatic impairment, splenomegaly and multiple chromosomal abnormalities that was treated initially with gemcitabine and steroids. Once liver function tests improved, six cycles of Adriamycin, bleomycin, vinblastine, and dacarbazine were administered. The patient remains in remission at 3.5 years of follow-up.
霍奇金淋巴瘤（HL）起源于克隆性B细胞，是第二个十年中最常见的恶性肿瘤。HL患者初诊时肝脏受累并不常见，且关于肝功能严重受损患者的治疗数据较少。我们报告了一例罕见的HL病例，该患者伴有严重肝功能损害、脾肿大和多种染色体异常，最初接受吉西他滨和类固醇治疗。一旦肝功能检查有所改善，便给予六个周期的阿霉素、博来霉素、长春花碱和达卡巴嗪治疗。随访3.5年，患者仍处于缓解期。
