a Centre of Dietetics Research, University of Queensland , St. Lucia , Queensland , Australia.
b National Institute of Integrative Medicine , Melbourne , Victoria , Australia.
Crit Rev Food Sci Nutr. 2017 Jan 2;57(1):141-146. doi: 10.1080/10408398.2013.865590.
Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.
尽管止吐治疗取得了进展，但化疗引起的恶心和呕吐（CINV）仍然给接受化疗的患者带来了重大负担。特别是在这一人群中，恶心仍然非常普遍。生姜一直被传统用作治疗胃肠道疾病的民间疗法，并被认为是癌症患者恶心和呕吐的一种可行的辅助治疗方法。大量研究表明，生姜具有多种特性，可对接受化疗并出现恶心和呕吐的患者产生多种有益影响。生姜根茎中的生物活性化合物，特别是姜酚和姜烯酚类化合物，与 CINV 直接相关的途径以及可能通过加剧症状而发挥次要作用的途径相互作用。这些特性包括 5-HT、P 物质和乙酰胆碱受体拮抗作用；抗炎特性；以及细胞氧化还原信号、血管加压素释放、胃肠道动力和胃排空率的调节。通过讨论化疗背景下以及其他相关领域的临床、体外和动物研究的结果，本文概述了这些拟议的机制。本综述中提出的证据表明，生姜具有多种特性，可有助于减轻 CINV。
