川崎病合并自身免疫性溶血性贫血
Kawasaki disease with autoimmune hemolytic anemia.
作者信息
Thakkar Dhwanee, Radhakrishnan Nita, Pruthi P K, Sachdeva Anupam
机构信息
Pediatric Hematology Oncology and BMT Unit; and *Institute of Child Health; Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India. Correspondence to: Dr Anupam Sachdeva, Head of Department, Institute of Child Health, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110 060, India.
出版信息
Indian Pediatr. 2015 Mar 8;52(3):245-6. doi: 10.1007/s13312-015-0617-y.
BACKGROUND
Association of autoimmune haemolytic anaemia has been seldom reported with Kawasaki disease.
CASE CHARACTERISTICS
A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.
OBSERVATIONS
Positive Direct Coombs test and coronary artery aneurysm on echocardiography. He was managed with steroids along with intravenous immunoglobulins and aspirin.
OUTCOME
Early identification of the condition helped in the management.
MESSAGE
Patients of autoimmune hemolytic anemia with unusual features such as prolonged fever, skin rash, and mixed antibody response in Coombs test should be evaluated for underlying Kawasaki disease as a possible etiology.
背景
自身免疫性溶血性贫血与川崎病的关联鲜有报道。
病例特征
一名7个月大的男孩，出现持续发热、红斑皮疹、严重苍白及肝脾肿大。
观察结果
直接抗人球蛋白试验阳性，超声心动图显示冠状动脉瘤。他接受了类固醇、静脉注射免疫球蛋白和阿司匹林治疗。
结局
对该病症的早期识别有助于治疗。
启示
对于具有持续发热、皮疹及抗人球蛋白试验混合抗体反应等不寻常特征的自身免疫性溶血性贫血患者，应评估是否存在潜在的川崎病作为可能病因。
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