在患有和未患阿尔茨海默病痴呆症的唐氏综合征个体中进行的氟代硼吡咯正电子发射断层扫描（Florbetapir PET）、氟脱氧葡萄糖正电子发射断层扫描（FDG PET）和磁共振成像（MRI）。

Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer's dementia.

作者信息

Sabbagh Marwan N, Chen Kewei, Rogers Joseph, Fleisher Adam S, Liebsack Carolyn, Bandy Dan, Belden Christine, Protas Hillary, Thiyyagura Pradeep, Liu Xiaofen, Roontiva Auttawut, Luo Ji, Jacobson Sandra, Malek-Ahmadi Michael, Powell Jessica, Reiman Eric M

机构信息

Banner Sun Health Research Institute, Sun City, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA; College of Medicine, University of Arizona, Phoenix, AZ, USA.

Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Arizona State University, Tempe, AZ, USA.

出版信息

Alzheimers Dement. 2015 Aug;11(8):994-1004. doi: 10.1016/j.jalz.2015.01.006. Epub 2015 Apr 4.

INTRODUCTION

Down syndrome (DS) is associated with amyloid b (Ab) deposition.

METHODS

We characterized imaging measurements of regional fibrillar Ab burden, cerebral metabolic rate for glucose (rCMRgl), gray matter volumes (rGMVs), and age associations in 5 DS with dementia (DS/AD1), 12 DS without dementia (DS/AD2), and 9 normal controls (NCs).

RESULTS

There were significant group differences in mean standard uptake value ratios (SUVRs) for florbetapir with DS/AD1 having the highest, followed by DS/AD2, followed by NC. For [18F]-fluorodeoxyglucose positron emission tomography, posterior cingulate rCMRgl in DS/AD1 was significantly reduced compared with DS/AD2 and NC. For volumetric magnetic resonance imaging (vMRI), hippocampal volumes were significantly reduced for the DS/AD1 compared with DS/AD2 and NC. Age-related SUVR increases and rCMRgl reductions were greater in DS participants than in NCs.

DISCUSSION

DS is associated with fibrillar Ab, rCMRgl, and rGMV alterations in the dementia stage and before the presence of clinical decline. This study provides a foundation for the studies needed to inform treatment and prevention in DS.

引言

唐氏综合征（DS）与淀粉样蛋白β（Ab）沉积有关。

方法

我们对5名患有痴呆症的唐氏综合征患者（DS/AD1）、12名未患痴呆症的唐氏综合征患者（DS/AD2）和9名正常对照者（NC）的区域纤维状Ab负荷、脑葡萄糖代谢率（rCMRgl）、灰质体积（rGMV）的成像测量以及年龄相关性进行了特征分析。

结果

氟代硼吡咯的平均标准摄取值比率（SUVRs）存在显著的组间差异，DS/AD1最高，其次是DS/AD2，然后是NC。对于[18F] - 氟脱氧葡萄糖正电子发射断层扫描，与DS/AD2和NC相比，DS/AD1的后扣带回rCMRgl显著降低。对于容积磁共振成像（vMRI），与DS/AD2和NC相比，DS/AD1的海马体积显著减小。与年龄相关的SUVR增加和rCMRgl降低在唐氏综合征参与者中比在正常对照者中更大。