McLachlan Max, Bettcher Brecca, McVea Andrew, DiFillipo Alexandra, Zammit Matthew, LeMerise Lisette, Rouanet Jeremy, Price Julie, Tudorascu Dana, Laymon Charles, Keator David, Lao Patrick, Brickman Adam M, Fryer Tim, Hartley Sigan, Ances Beau M, Johnson Sterling, Betthauser Tobey, Stone Charles K, Zaman Shahid, Handen Benjamin, Head Elizabeth, Mapstone Mark, Christian Bradley T
University of Wisconsin-Madison, Madison, WI, USA.
University of California, Irvine, Irvine, CA, USA.
medRxiv. 2024 Dec 6:2024.12.04.24318526. doi: 10.1101/2024.12.04.24318526.
Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [C]PiB PET imaging, which has not been replicated with [F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.
Longitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding. Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.
PiB demonstrated greater striatal-to-cortical ratios than FBP. SILA analysis revealed striatal amyloid burden occurs 3.40 (2.39) years earlier than the cortex in PiB. There was no difference between the cortex and striatum in FBP.
Among adults with Down syndrome, the striatum consistently accumulates amyloid earlier than the cortex when measured with PiB. This suggests the striatum is more sensitive to the onset of PiB PET-detectable amyloid in Down syndrome.
唐氏综合征成年人在[C]匹兹堡化合物B（PiB）正电子发射断层扫描（PET）成像中显示纹状体先于淀粉样蛋白积累，而[F]氟代硼替佐米（FBP）尚未复制这一现象。早期纹状体积累尚未相对于全脑皮质测量进行时间量化。
来自阿尔茨海默病生物标志物联盟 - 唐氏综合征的纵向PiB（n = 175名参与者）和FBP（n = 92名参与者）数据用于测量皮质和纹状体结合。使用采样迭代局部近似（SILA）方法创建皮质和纹状体淀粉样蛋白积累的广义时间模型。
PiB显示出比FBP更高的纹状体与皮质比值。SILA分析显示，在PiB中，纹状体淀粉样蛋白负担比皮质早3.40（2.39）年出现。FBP中皮质和纹状体之间没有差异。
在唐氏综合征成年人中，用PiB测量时，纹状体始终比皮质更早积累淀粉样蛋白。这表明纹状体对唐氏综合征中PiB PET可检测淀粉样蛋白的发病更敏感。
