St Croix Brad
Tumor Angiogenesis Section, Mouse Cancer Genetics Program, National Cancer Institute (NCI), NIH, Frederick, MD 21702, USA.
Cell Res. 2015 May;25(5):533-4. doi: 10.1038/cr.2015.42. Epub 2015 Apr 7.
Netrin-1, a classic neuronal guidance cue, can promote angiogenesis under certain developmental and pathological conditions, but key receptors on vascular endothelium have remained elusive. A recent study published in Cell Research by Tu et al. reveals that CD146, an endothelial receptor of the immunoglobulin superfamily, binds netrin-1 with high affinity and may play an important role in regulating angiogenesis.
神经纤毛蛋白-1（Netrin-1）是一种经典的神经元导向因子，在某些发育和病理条件下可促进血管生成，但其在血管内皮细胞上的关键受体仍不明确。屠等人近期发表于《细胞研究》的一项研究表明，免疫球蛋白超家族的内皮细胞受体CD146与神经纤毛蛋白-1具有高亲和力结合，可能在调节血管生成中发挥重要作用。
