人类原生动物寄生虫中的非常规肌动蛋白和肌动蛋白结合蛋白。
Unconventional actins and actin-binding proteins in human protozoan parasites.
作者信息
Gupta C M, Thiyagarajan S, Sahasrabuddhe A A
机构信息
Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City, Phase I, Bangalore 560100, India.
Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City, Phase I, Bangalore 560100, India.
出版信息
Int J Parasitol. 2015 Jun;45(7):435-47. doi: 10.1016/j.ijpara.2015.01.011. Epub 2015 Apr 4.
Actin and its regulatory proteins play a key role in several essential cellular processes such as cell movement, intracellular trafficking and cytokinesis in most eukaryotes. While these proteins are highly conserved in higher eukaryotes, a number of unicellular eukaryotic organisms contain divergent forms of these proteins which have highly unusual biochemical and structural properties. Here, we review the biochemical and structural properties of these unconventional actins and their core binding proteins which are present in commonly occurring human protozoan parasites.
肌动蛋白及其调节蛋白在大多数真核生物的多种基本细胞过程中发挥关键作用，如细胞运动、细胞内运输和胞质分裂。虽然这些蛋白在高等真核生物中高度保守，但许多单细胞真核生物含有这些蛋白的不同形式，它们具有非常不寻常的生化和结构特性。在这里，我们综述了常见人类原生动物寄生虫中存在的这些非常规肌动蛋白及其核心结合蛋白的生化和结构特性。
Zotero 插件