de la Rosa Victor R, Nau Werner M, Hoogenboom Richard
Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, 9000 Ghent, Belgium.
Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, D 28759 Bremen, Germany.
Int J Mol Sci. 2015 Apr 2;16(4):7428-44. doi: 10.3390/ijms16047428.
A series of water insoluble poly[(2-ethyl-2-oxazoline)-ran-(2-nonyl-2-oxazoline)] amphiphilic copolymers was synthesized and their solubility properties in the presence of different supramolecular host molecules were investigated. The resulting polymer-cavitand assemblies exhibited a thermoresponsive behavior that could be modulated by variation of the copolymer composition and length. Interestingly, the large number of hydrophobic nonyl units across the polymer chain induced the formation of kinetically-trapped nanoparticles in solution. These nanoparticles further agglomerate into larger aggregates at a temperature that is dependent on the polymer composition and the cavitand type and concentration. The present research expands the understanding on the supramolecular interactions between water insoluble copolymers and supramolecular host molecules.
合成了一系列水不溶性聚[(2-乙基-2-恶唑啉)-无规-(2-壬基-2-恶唑啉)]两亲共聚物，并研究了它们在不同超分子主体分子存在下的溶解性能。所得的聚合物-穴状配体组装体表现出热响应行为，该行为可通过共聚物组成和长度的变化进行调节。有趣的是，聚合物链上大量的疏水壬基单元导致在溶液中形成动力学捕获的纳米颗粒。这些纳米颗粒在取决于聚合物组成、穴状配体类型和浓度的温度下进一步聚集成更大的聚集体。本研究扩展了对水不溶性共聚物与超分子主体分子之间超分子相互作用的理解。
