Wilson Rachel Dorothy, Islam Md Shahidul
Acta Pol Pharm. 2015 Jan-Feb;72(1):153-60.
The present study was aimed to investigate the anti-diabetic effects of a low (0.25%) and a high (0.5%) dose of white mulberry leaf tea in a rat model of type 2 diabetes (T2D). Six week old male Sprague-Dawley rats were divided into four groups: Normal control (NC), Diabetic control (DBC), Diabetic mulberry tea low (DMTL, 0.25%) and Diabetic mulberry tea high (DMTH, 0.50%). T2D was induced by feeding a 10% fructose solution in drinking water for 2 weeks to induce insulin resistance, followed by a single injection (i.p.) of streptozotocin (40 mg/kg body weight (b.w.)) to induce partial pancreatic β-cell dysfunction in all groups except the NC group, which only received a normal drinking water and citrate buffer (pH 4.4) instead of fructose solution and STZ injection, respectively. After 4 weeks feeding of brewed mulberry leaf tea, there were no significant improvements in polyphagia, polydipsia, body weight gain, blood glucose, glucose intolerance, serum insulin, fructosamine, AST, ALT, creatinine, albumin and uric acid levels and liver parameters when serum total cholesterol was significantly and LDL-cholesterol and triglyceride concentrations were markedly decreased in the DMTH group compared to the DBC and DMTL groups. Serum total proteins were significantly reduced in DMTL and DMTH groups compared to the DBC group. These results suggest that brewed white mulberry leaf tea has hypolipidemic rather than antidiabetic effects at least in this experimental condition. However, the effects of the different brands of white mulberry leaf tea may be varied due to various factors.
本研究旨在探讨低剂量（0.25%）和高剂量（0.5%）的白桑叶茶对2型糖尿病（T2D）大鼠模型的抗糖尿病作用。六周龄雄性斯普拉格-道利大鼠分为四组：正常对照组（NC）、糖尿病对照组（DBC）、低剂量糖尿病桑叶茶组（DMTL，0.25%）和高剂量糖尿病桑叶茶组（DMTH，0.50%）。通过在饮用水中喂食10%果糖溶液2周诱导胰岛素抵抗，随后对除NC组外的所有组腹腔注射（i.p.）链脲佐菌素（40 mg/kg体重（b.w.））以诱导部分胰腺β细胞功能障碍，NC组仅分别接受正常饮用水和柠檬酸盐缓冲液（pH 4.4），而非果糖溶液和链脲佐菌素注射。喂食冲泡的桑叶茶4周后，与DBC组和DMTL组相比，DMTH组在多食、多饮、体重增加、血糖、葡萄糖耐量、血清胰岛素、果糖胺、AST、ALT、肌酐、白蛋白和尿酸水平以及肝脏参数方面均无显著改善，但血清总胆固醇显著降低，低密度脂蛋白胆固醇和甘油三酯浓度明显下降。与DBC组相比，DMTL组和DMTH组的血清总蛋白显著降低。这些结果表明，至少在本实验条件下，冲泡的白桑叶茶具有降血脂作用而非抗糖尿病作用。然而，由于各种因素，不同品牌的白桑叶茶的效果可能会有所不同。
