Vyas Nikki S, Lawrence Kelsey L, Griffith James L, Hamzavi Iltefat H
University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Wayne State University School of Medicine, Detroit, MI, USA.
J Cutan Med Surg. 2015 Sep-Oct;19(5):488-93. doi: 10.1177/1203475415581311. Epub 2015 Apr 7.
Melanocyte-keratinocyte transplant procedure (MKTP) successfully repigments postburn leukodermic scars.
To further investigate the efficacy and limitations of MKTP for treatment of mechanically and chemically induced leukodermic scars.
Ten patients with mechanically or chemically induced, depigmented or hypopigmented scars were preoperatively evaluated with Wood's light examination, treated with MKTP, and followed for at least 6 months, with monitoring of repigmentation and colour matching.
Nine patients attended at least 6 months of follow-up. Six patients showed no fluorescence of scars under Wood's lamp. All patients whose lesions didn't fluoresce displayed less than 50% repigmentation, with 5 of 6 attaining 0% to 24%. Of the 3 patients displaying bright or some fluorescence, more than 95% repigmentation was achieved in 2 patients (skin phototypes V and VI), while less than 24% was attained for the third (skin phototype II).
In this small case series, lack of fluorescence in leukodermic scars may be a useful negative prognostic indicator for MKTP, but additional trials are needed to verify that this is not due to melanocompetency.
黑素细胞-角质形成细胞移植术（MKTP）可成功使烧伤后白色瘢痕重新着色。
进一步研究MKTP治疗机械性和化学性所致白色瘢痕的疗效及局限性。
对10例机械性或化学性所致色素脱失或色素减退瘢痕患者术前进行伍德灯检查评估，采用MKTP治疗，并随访至少6个月，监测色素重新沉着及颜色匹配情况。
9例患者接受了至少6个月的随访。6例患者的瘢痕在伍德灯下无荧光。所有瘢痕无荧光的患者色素重新沉着均不到50%，6例中有5例达到0%至24%。3例显示明亮荧光或有一些荧光的患者中，2例（皮肤光型V和VI）色素重新沉着超过95%，而第3例（皮肤光型II）则不到24%。
在这个小病例系列中，白色瘢痕缺乏荧光可能是MKTP预后不良的一个有用指标，但需要更多试验来证实这并非由于黑素细胞功能所致。
