自体黑素细胞-角质形成细胞悬液治疗白癜风。
Autologous melanocyte-keratinocyte suspension in the treatment of vitiligo.
机构信息
Department of Dermatology, Faculty of Medicine, Kasr El-Aini University Hospital, Cairo University, Cairo, Egypt.
出版信息
J Eur Acad Dermatol Venereol. 2011 Feb;25(2):215-20. doi: 10.1111/j.1468-3083.2010.03759.x. Epub 2010 Jun 21.
BACKGROUND
In stable vitiligo, several techniques of autologous transplantation of melanocytes are used. Autologous melanocyte transplantation of non-cultured melanocytes is one of those techniques with variable reported outcomes.
OBJECTIVE
The objective of this study was to evaluate the response to autologous melanocyte-keratinocytes suspension transplantation in cases of stable vitiligo.
METHODS
A total of 25 cases of vitiligo were treated by autologous melanocyte-keratinocytes suspension transplantation. After 6-17 months, patients' response was evaluated according to the extent of pigmentation (excellent 90-100%, good 50-89%, fair 20-49% and poor response <20%).
RESULTS
Of the 25 patients treated, 22 continued the follow-up period. Five (23%) patients showed excellent response, 7 (32%) good, 6 (27%) fair and 4(18%) showed poor response.
CONCLUSION
Unlike transplantation of cultured melanocytes, which requires experience in culture technique, autologous melanocyte-keratinocytes suspension transplantation is an easy economic technique, which may be used in resistant areas of stable vitiligo.
背景
在稳定期白癜风中，使用了几种自体黑素细胞移植技术。非培养黑素细胞的自体黑素细胞移植是其中一种技术，但报道的结果各不相同。
目的
本研究旨在评估自体黑素细胞-角质形成细胞悬浮液移植治疗稳定期白癜风的疗效。
方法
对 25 例白癜风患者进行自体黑素细胞-角质形成细胞悬浮液移植治疗。6-17 个月后，根据色素沉着程度（优 90-100%、良 50-89%、中 20-49%和差反应 <20%）评估患者的反应。
结果
25 例患者中，22 例继续随访。5 例（23%）患者表现出优效，7 例（32%）良效，6 例（27%）中效，4 例（18%）差效。
结论
与需要培养技术经验的培养黑素细胞移植不同，自体黑素细胞-角质形成细胞悬浮液移植是一种简单、经济的技术，可用于稳定期白癜风的难治性部位。
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