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肥胖患者行袖状胃切除术与Roux-en-Y胃旁路术后胆结石发生率的比较:一项前瞻性研究。

Comparison of the incidence of cholelithiasis after sleeve gastrectomy and Roux-en-Y gastric bypass in obese patients: a prospective study.

作者信息

Coupaye Muriel, Castel Benjamin, Sami Ouidad, Tuyeras Géraud, Msika Simon, Ledoux Séverine

机构信息

Service des Explorations Fonctionnelles, Centre de référence de prise en charge de l'obésité, Hôpital Louis Mourier (AP-HP), Université Paris Diderot, Sorbonne Paris Cité, France.

Service de Chirurgie, Centre de référence de prise en charge de l'obésité, Hôpital Louis Mourier (AP-HP), Université Paris Diderot, Sorbonne Paris Cité, France.

出版信息

Surg Obes Relat Dis. 2015 Jul-Aug;11(4):779-84. doi: 10.1016/j.soard.2014.10.015. Epub 2014 Oct 23.

Abstract

BACKGROUND

Although the risk of cholelithiasis (CL) increases in patients after Roux-en-Y gastric bypass (RYGB), no prospective study has yet assessed the incidence of CL after sleeve gastrectomy (SG).

OBJECTIVES

To compare, prospectively, the incidence and predictive factors for CL after both procedures.

METHODS

A postoperative abdominal ultrasound follow-up was proposed to all patients with an intact gallbladder and who underwent RYGB or SG in Hôpital Louis Mourier from 2008 onward.

RESULTS

At least one ultrasound was performed on one hundred and sixty patients between 6 and 12 months postsurgery, 43 after SG and 117 after RYGB. Age, gender, initial body-mass index, co-morbidities were similar in both groups. Weight loss (WL) at 6 months was significantly lower after SG than after RYGB (26.9 ± 9.2 and 31.3 ± 7.5 kg, respectively = .001). The incidences of CL after SG and RYGB were similar (28% versus 34% respectively, P = .57). Most cases of CL occurred in the first year post surgery. During the follow-up, 12% and 13% of patients who underwent SG and RYGB, respectively, became symptomatic. WL of>30 kg at 6 months was a risk factor for CL after bariatric surgery, but we did not find any preoperative predictive factor for gallstone formation.

CONCLUSIONS

Despite lower WL after SG, the incidence of CL after SG and RYGB was similar at 2 years. Our results suggest that rapid WL is the main element leading to gallstone formation after both procedures.

摘要

背景

尽管Roux-en-Y胃旁路术(RYGB)后患者患胆石症(CL)的风险增加,但尚无前瞻性研究评估袖状胃切除术(SG)后CL的发生率。

目的

前瞻性比较两种手术术后CL的发生率及预测因素。

方法

自2008年起,对路易·穆里埃医院所有胆囊完整且接受RYGB或SG手术的患者进行术后腹部超声随访。

结果

160例患者在术后6至12个月至少接受了一次超声检查,其中43例接受SG手术,117例接受RYGB手术。两组患者的年龄、性别、初始体重指数、合并症相似。SG术后6个月的体重减轻(WL)明显低于RYGB术后(分别为26.9±9.2和31.3±7.5kg,P=0.001)。SG和RYGB术后CL的发生率相似(分别为28%和34%,P=0.57)。大多数CL病例发生在术后第一年。随访期间,接受SG和RYGB手术患者分别有12%和13%出现症状。减重手术后6个月体重减轻>30kg是CL的危险因素,但我们未发现任何术前胆石形成的预测因素。

结论

尽管SG术后WL较低,但SG和RYGB术后2年CL的发生率相似。我们的结果表明,快速体重减轻是两种手术后导致胆石形成的主要因素。

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