Li Yu-Ying, Ding Yue-Min, Zhang Xiong
Zhejiang University School of Medcine,Hangzhou 310058,China.
School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Jan;44(1):95-100. doi: 10.3785/j.issn.1008-9292.2015.01.016.
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. MMPs can degrade and remodel extracellular matrix, also active or inactive many molecules attaching to matrix including receptors, growth factors and cytokines, so that injury-induced MMPs can change the extracellular environment to affect the axonal regeneration in central nervous system. In this review, with spinal cord injury (SCI) as an example we discuss the effects of MMPs on inflammation, neuronal viability, extracellular molecules, glial scar and axonal remyelination, which are all important to axonal regeneration.
基质金属蛋白酶（MMPs）是锌依赖性内肽酶。MMPs 能够降解并重塑细胞外基质，还能激活或失活许多附着于基质的分子，包括受体、生长因子和细胞因子，因此损伤诱导产生的 MMPs 可改变细胞外环境，从而影响中枢神经系统的轴突再生。在本综述中，我们以脊髓损伤（SCI）为例，探讨 MMPs 对炎症、神经元活力、细胞外分子、胶质瘢痕和轴突再髓鞘化的影响，这些均对轴突再生至关重要。
