Halwani Yasmin, Kojic Liliana D, Chan Simon K, Phang Terry P, Masoudi Hamid, Jones Steven J M, Nabi Ivan R, Wiseman Sam M
Department of Surgery, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Am J Surg. 2015 May;209(5):884-9; discussion 889. doi: 10.1016/j.amjsurg.2015.01.010. Epub 2015 Mar 14.
Autocrine motility factor receptor (AMFR) has been linked to metastasis and tumorigenicity. The aim of this study was to evaluate expression and prognostic significance of AMFR in colorectal carcinoma.
AMFR expression was evaluated in 127 colon cancer specimens, 131 rectal cancer specimens, and 47 colonic and 25 rectal corresponding lymph node metastases. Clinicopathological correlates of prognostic significance were established by univariate and multivariate analysis. Spearman's correlation determined the association of expression between cancers and their metastases.
AMFR was over-expressed by 22% of colon cancers and 18% of rectal cancers. AMFR over-expression correlated significantly with improved disease-free survival (DFS) (P < .05) in colon cancer and decreased DFS in corresponding nodal metastases. In rectal cancer, AMFR over-expression significantly correlated with decreased overall survival, DFS, and disease-specific survival (P < .001, P = .031, P = .005, respectively) and decreased overall survival in corresponding metastases.
AMFR may serve as a molecular prognosticator for colon cancer and rectal cancer.
自分泌运动因子受体（AMFR）与转移和肿瘤发生有关。本研究旨在评估AMFR在结直肠癌中的表达及其预后意义。
对127例结肠癌标本、131例直肠癌标本以及47例结肠和25例直肠相应淋巴结转移灶进行AMFR表达评估。通过单因素和多因素分析确定具有预后意义的临床病理相关性。Spearman相关性分析确定癌症与其转移灶之间的表达关联。
22%的结肠癌和18%的直肠癌中AMFR呈过表达。在结肠癌中，AMFR过表达与无病生存期（DFS）改善显著相关（P <.05），而在相应的淋巴结转移灶中DFS降低。在直肠癌中，AMFR过表达与总生存期、DFS和疾病特异性生存期降低显著相关（分别为P <.001、P =.031、P =.005），且在相应转移灶中总生存期降低。
AMFR可能作为结肠癌和直肠癌的分子预后指标。
