van Vuren A J, de Jong B, Bootsma H P R, Van der Veen M J, Feith G W
Gelre Hospitals, Apeldoorn, the Netherlands.
Neth J Med. 2015 Mar;73(3):136-8.
Renal function deterioration is a rather frequent side effect of ticagrelor; this is especially so in patients over the age of 75, with pre-existent mild renal failure and/or taking an angiotensin receptor inhibitor. We describe a patient in whom deterioration of renal function due to ticagrelor led to a rise in serum concentration of rosuvastatin which resulted in rhabdomyolysis. The presented case emphasises the importance to check renal function routinely before and one month after starting ticagrelor and to screen carefully for possible interactions with other drugs.
肾功能恶化是替格瑞洛相当常见的副作用；在75岁以上、已有轻度肾衰竭和/或正在服用血管紧张素受体抑制剂的患者中尤其如此。我们描述了一名患者，替格瑞洛导致的肾功能恶化致使瑞舒伐他汀血清浓度升高，进而引发横纹肌溶解。该病例强调了在开始使用替格瑞洛之前及之后1个月常规检查肾功能，并仔细筛查与其他药物可能存在的相互作用的重要性。
