成瘾的大脑：理解成瘾性障碍的神经生理机制 - Suppr

Suppr

超能文献

The addicted brain: understanding the neurophysiological mechanisms of addictive disorders.

作者信息

Herman Melissa A, Roberto Marisa

机构信息

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute La Jolla, CA, USA.

出版信息

Front Integr Neurosci. 2015 Mar 19;9:18. doi: 10.3389/fnint.2015.00018. eCollection 2015.

DOI:10.3389/fnint.2015.00018

PMID:25852502

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4365688/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c875/4365688/5e7afd300dc6/fnint-09-00018-g0001.jpg

相似文献

The addicted brain: understanding the neurophysiological mechanisms of addictive disorders.成瘾的大脑：理解成瘾性障碍的神经生理机制

Front Integr Neurosci. 2015 Mar 19;9:18. doi: 10.3389/fnint.2015.00018. eCollection 2015.

Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine.长期暴露于尼古丁、乙醇或可卡因的大鼠大脑中内源性大麻素含量的变化。

Brain Res. 2002 Nov 1;954(1):73-81. doi: 10.1016/s0006-8993(02)03344-9.

Is nicotine more addictive than cocaine?尼古丁比可卡因更易上瘾吗？

Br J Addict. 1991 May;86(5):565-9. doi: 10.1111/j.1360-0443.1991.tb01809.x.

Efficacy and side effects of baclofen and the novel GABA receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction.巴氯芬和新型 GABA 受体正变构调节剂 CMPPE 在酒精和可卡因成瘾动物模型中的疗效和副作用。

Psychopharmacology (Berl). 2018 Jul;235(7):1955-1965. doi: 10.1007/s00213-018-4893-9. Epub 2018 Apr 12.

Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction.甲基苯丙胺对可卡因成瘾者眶额皮质和内侧前额叶皮质有激活作用，而对对照组则无此作用：与成瘾的相关性。

J Neurosci. 2005 Apr 13;25(15):3932-9. doi: 10.1523/JNEUROSCI.0433-05.2005.

Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid.酒精与可卡因、甲基苯丙胺、阿片类药物、尼古丁、大麻及γ-羟基丁酸的相互作用

Biomedicines. 2019 Mar 7;7(1):16. doi: 10.3390/biomedicines7010016.

Differential Effects of Addictive Drugs on Sleep and Sleep Stages.成瘾性药物对睡眠及睡眠阶段的不同影响。

J Addict Res (OPAST Group). 2019;3(2). doi: 10.33140/JAR.03.02.01. Epub 2019 Jul 15.

Common biology of craving across legal and illegal drugs - a quantitative meta-analysis of cue-reactivity brain response.各种合法与非法药物成瘾的共同生物学基础：基于线索反应的大脑反应的定量荟萃分析。

Eur J Neurosci. 2011 Apr;33(7):1318-26. doi: 10.1111/j.1460-9568.2010.07590.x. Epub 2011 Jan 24.

Epigenetic mechanisms associated with addiction-related behavioural effects of nicotine and/or cocaine: implication of the endocannabinoid system.与尼古丁和/或可卡因成瘾相关行为效应有关的表观遗传机制：内源性大麻素系统的影响

Behav Pharmacol. 2017 Oct;28(7):493-511. doi: 10.1097/FBP.0000000000000326.

Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U.S. population.美国人口中去年酒精、尼古丁、大麻和可卡因依赖症状的患病率及人口统计学关联。

Drug Alcohol Depend. 1997 Jan 10;44(1):11-29. doi: 10.1016/s0376-8716(96)01315-4.

引用本文的文献

Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis.物质使用障碍的常见神经模式：基于种子点的静息态功能连接荟萃分析。

Transl Psychiatry. 2025 Jun 4;15(1):190. doi: 10.1038/s41398-025-03396-2.

Neurophysiological correlates of trait and behavioral impulsivity across methamphetamine and gambling Addiction.甲基苯丙胺成瘾和赌博成瘾中特质冲动性与行为冲动性的神经生理学关联

Heliyon. 2024 Nov 7;10(23):e40212. doi: 10.1016/j.heliyon.2024.e40212. eCollection 2024 Dec 15.

Different development patterns of reward behaviors induced by ketamine and JWH-018 in striatal GAD67 knockdown mice.不同的奖赏行为发展模式由氯胺酮和 JWH-018 在纹状体 GAD67 敲低小鼠中诱导。

J Vet Sci. 2024 Sep;25(5):e63. doi: 10.4142/jvs.23325. Epub 2024 Aug 12.

The Role of Acupuncture in Treating a Patient with a Gambling Disorder.针刺疗法在治疗一名赌博障碍患者中的作用。

Med Acupunct. 2022 Oct 1;34(5):331-336. doi: 10.1089/acu.2021.0013. Epub 2022 Oct 17.

Independent of differences in taste, B6N mice consume less alcohol than genetically similar B6J mice, and exhibit opposite polarity modulation of tonic GABAR currents by alcohol.与味觉差异无关，B6N小鼠比基因相似的B6J小鼠摄入的酒精更少，并且酒精对其强直型GABAR电流表现出相反的极性调节。

Neuropharmacology. 2022 Mar 15;206:108934. doi: 10.1016/j.neuropharm.2021.108934. Epub 2021 Dec 20.

The cognitive and behavioral effects of D-amphetamine and nicotine sensitization in adult zebrafish.D-苯丙胺和尼古丁敏化对成年斑马鱼认知和行为的影响。

Psychopharmacology (Berl). 2021 Aug;238(8):2191-2200. doi: 10.1007/s00213-021-05844-5. Epub 2021 May 8.

Catechol-O-methyltransferase and dopamine receptor D4 gene variants: Possible association with substance abuse in Bangladeshi male.儿茶酚氧位甲基转移酶和多巴胺受体 D4 基因变异：可能与孟加拉国男性物质滥用有关。

PLoS One. 2021 Feb 5;16(2):e0246462. doi: 10.1371/journal.pone.0246462. eCollection 2021.

Exposure to Commercial Cigarette Smoke Produces Psychomotor Sensitization Via Hyperstimulation of Glutamate Response in the Dorsal Striatum.接触商业香烟烟雾通过过度刺激背侧纹状体中的谷氨酸反应产生精神运动致敏。

Brain Sci. 2020 Dec 24;11(1):14. doi: 10.3390/brainsci11010014.

The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function.自由运动模式 Y 迷宫：一种跨物种的工作记忆和执行功能测量方法。

Behav Res Methods. 2021 Apr;53(2):536-557. doi: 10.3758/s13428-020-01452-x.

Interactions between monoamine oxidase A rs1137070 and smoking on brain structure and function in male smokers.单胺氧化酶A基因rs1137070与吸烟对男性吸烟者脑结构和功能的相互作用。

Eur J Neurosci. 2019 Aug;50(3):2201-2210. doi: 10.1111/ejn.14282. Epub 2018 Dec 11.

本文引用的文献

Dopamine systems adaptation during acquisition and consolidation of a skill.技能习得与巩固过程中多巴胺系统的适应性变化

Front Integr Neurosci. 2014 Nov 5;8:87. doi: 10.3389/fnint.2014.00087. eCollection 2014.

Chronic ethanol alters network activity and endocannabinoid signaling in the prefrontal cortex.慢性乙醇改变前额叶皮层的网络活动和内源性大麻素信号。

Front Integr Neurosci. 2014 Jul 18;8:58. doi: 10.3389/fnint.2014.00058. eCollection 2014.

Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP.急性吗啡在纳洛酮诱发的吗啡戒断期间改变了中杏仁核的 GABA 能传递：环 AMP 的作用。

Front Integr Neurosci. 2014 Jun 4;8:45. doi: 10.3389/fnint.2014.00045. eCollection 2014.

Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal.杏仁核和前额皮质 PDE10A 表达在急性和慢性戒断期间的差异变化。

Front Integr Neurosci. 2014 Apr 8;8:30. doi: 10.3389/fnint.2014.00030. eCollection 2014.

CCL2-ethanol interactions and hippocampal synaptic protein expression in a transgenic mouse model.CCL2-乙醇相互作用和转基因小鼠模型中海马突触蛋白表达。

Front Integr Neurosci. 2014 Apr 4;8:29. doi: 10.3389/fnint.2014.00029. eCollection 2014.

Neuronal extracellular signal-regulated kinase (ERK) activity as marker and mediator of alcohol and opioid dependence.神经元细胞外信号调节激酶 (ERK) 活性作为酒精和阿片依赖的标志物和介质。

Front Integr Neurosci. 2014 Mar 11;8:24. doi: 10.3389/fnint.2014.00024. eCollection 2014.

Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum.急性与反复可卡因暴露对小鼠小脑内源性大麻素信号相关蛋白表达的影响。

Front Integr Neurosci. 2014 Mar 5;8:22. doi: 10.3389/fnint.2014.00022. eCollection 2014.

MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala.MT-7716，一种新型选择性非肽类 NOP 受体激动剂，能有效阻断乙醇诱导的大鼠中枢杏仁核 GABA 能传递的增加。

Front Integr Neurosci. 2014 Feb 18;8:18. doi: 10.3389/fnint.2014.00018. eCollection 2014.

Acute ethanol exposure inhibits silencing of cerebellar Golgi cell firing induced by granule cell axon input.急性乙醇暴露抑制颗粒细胞轴突输入诱导的小脑高尔基细胞放电沉默。

Front Integr Neurosci. 2014 Feb 6;8:10. doi: 10.3389/fnint.2014.00010. eCollection 2014.

Lateral/basolateral amygdala serotonin type-2 receptors modulate operant self-administration of a sweetened ethanol solution via inhibition of principal neuron activity.外侧/基底外侧杏仁核 5-羟色胺 2 型受体通过抑制主神经元活动调节加糖乙醇溶液的操作性自我给药。

Front Integr Neurosci. 2014 Jan 30;8:5. doi: 10.3389/fnint.2014.00005. eCollection 2014.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验