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骨骼健康方面的种族差异。

Ethnic differences in bone health.

作者信息

Zengin Ayse, Prentice Ann, Ward Kate Anna

机构信息

Medical Research Council Human Nutrition Research , Cambridge , UK.

Medical Research Council Human Nutrition Research , Cambridge , UK ; Medical Research Council , Keneba , Gambia.

出版信息

Front Endocrinol (Lausanne). 2015 Mar 17;6:24. doi: 10.3389/fendo.2015.00024. eCollection 2015.

Abstract

There are differences in bone health between ethnic groups in both men and in women. Variations in body size and composition are likely to contribute to reported differences. Most studies report ethnic differences in areal bone mineral density (aBMD), which do not consistently parallel ethnic patterns in fracture rates. This suggests that other parameters beside aBMD should be considered when determining fracture risk between and within populations, including other aspects of bone strength: bone structure and microarchitecture, as well as muscle strength (mass, force generation, anatomy) and fat mass. We review what is known about differences in bone-densitometry-derived outcomes between ethnic groups and the extent to which they account for the differences in fracture risk. Studies are included that were published primarily between 1994 and 2014. A "one size fits all approach" should definitely not be used to understand better ethnic differences in fracture risk.

摘要

男性和女性不同种族之间的骨骼健康存在差异。体型和身体成分的差异可能是报告中差异的原因。大多数研究报告了不同种族之间在骨面积密度(aBMD)上的差异,但这些差异与骨折发生率的种族模式并不一致。这表明,在确定不同人群之间以及人群内部的骨折风险时,除了骨面积密度之外,还应考虑其他参数,包括骨骼强度的其他方面:骨骼结构和微结构,以及肌肉力量(质量、力量产生、解剖结构)和脂肪量。我们回顾了不同种族之间骨密度测量结果差异的已知情况,以及这些差异在多大程度上解释了骨折风险的差异。纳入的研究主要发表于1994年至2014年之间。绝不应采用“一刀切”的方法来更好地理解不同种族在骨折风险方面的差异。

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