Luput-Andrica Ioana-Melinda, Marinescu Adelina-Raluca, Cut Talida Georgiana, Herlo Alexandra, Herlo Lucian-Flavius, Saizu Andra-Elena, Laza Ruxandra, Lustrea Anca, Floruncut Andreea-Cristina, Chisalita Adina, Nicolescu Narcisa, Oancea Cristian Iulian, Manolescu Diana, Jumanca Romanita, Rosoha Daniela-Ica, Lazureanu Voichita Elena
Doctoral School, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
Department XIII, Discipline of Infectious Diseases, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
Microorganisms. 2025 Jul 29;13(8):1768. doi: 10.3390/microorganisms13081768.
Human Immunodeficiency Virus (HIV) infection remains a major global health issue, with effective antiretroviral therapy (ART) extending life expectancy but also increasing age-related issues like osteopenia and osteoporosis. This cross-sectional study examines bone mineral density (BMD) and related risk factors in Romanian HIV-positive patients, emphasizing regional and therapy influences. The patients varying in HIV infection duration underwent DXA scanning to measure BMD in the lumbar spine, femoral neck, and total femur. A high prevalence of low BMD, especially in the lumbar spine, was identified along with significant associations between reduced BMD and factors such as smoking, alcohol use, vitamin D deficiency and serum phosphorus levels. ART like Protease Inhibitors and Nucleoside Reverse Transcriptase Inhibitors were linked to increased bone loss, emphasizing the multifactorial nature of osteoporosis in HIV-infected individuals and underscore the importance of regular BMD assessments, lifestyle adjustments, and careful management of antiretroviral therapy to minimize fracture risk and enhance overall health and quality of life.
人类免疫缺陷病毒（HIV）感染仍然是一个重大的全球健康问题，有效的抗逆转录病毒疗法（ART）虽然延长了预期寿命，但也增加了诸如骨质减少和骨质疏松等与年龄相关的问题。这项横断面研究调查了罗马尼亚HIV阳性患者的骨矿物质密度（BMD）及相关风险因素，重点关注地区和治疗的影响。对不同HIV感染持续时间的患者进行了双能X线吸收法（DXA）扫描，以测量腰椎、股骨颈和全股骨的骨密度。研究发现低骨密度的患病率很高，尤其是在腰椎，同时还发现骨密度降低与吸烟、饮酒、维生素D缺乏和血清磷水平等因素之间存在显著关联。蛋白酶抑制剂和核苷类逆转录酶抑制剂等抗逆转录病毒疗法与骨质流失增加有关，这凸显了HIV感染者骨质疏松的多因素性质，并强调了定期进行骨密度评估、调整生活方式以及谨慎管理抗逆转录病毒疗法以将骨折风险降至最低并提高整体健康和生活质量的重要性。
