Guimaraes D S, Amaral A P, Prado L F, Nascimento A G
Service of Anatomic Pathology, Instituto Nacional de Cancer, Rio de Janeiro, Brazil.
J Oral Pathol Med. 1989 Aug;18(7):396-9. doi: 10.1111/j.1600-0714.1989.tb01571.x.
Sixteen cases of acinic cell carcinoma (ACC) of salivary glands were studied and their different clinicopathologic aspects were analysed. ACC occurred more frequently in the 5th and 6th decades of life, and was seen exclusively in major salivary glands. The main complaint of the patients was the presence of a mass, and the majority of the tumors were Stage III and IV when first seen in our institution. The tumors were divided into three histologic grades based on cellular pleomorphism, mitotic activity, and necrosis. This study showed correlation between prognosis and grading. Other important factors in the prognosis were the type of treatment and the duration of symptoms. Surgical resection with free margins is the treatment of choice.
对16例涎腺腺泡细胞癌（ACC）进行了研究，并分析了其不同的临床病理特征。ACC在50至60岁人群中更为常见，且仅见于大涎腺。患者的主要主诉为肿块，在我院初诊时，大多数肿瘤为Ⅲ期和Ⅳ期。根据细胞多形性、有丝分裂活性和坏死情况，将肿瘤分为三个组织学分级。本研究表明预后与分级之间存在相关性。预后的其他重要因素包括治疗类型和症状持续时间。首选切缘阴性的手术切除治疗。
