蛋白质组学——牙周病学的研究前沿。
Proteomics - The research frontier in periodontics.
作者信息
Gupta Abhaya, Govila Vivek, Saini Ashish
机构信息
MDS (IIIrd Year) Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
MDS (Professor & Head of Department), Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
出版信息
J Oral Biol Craniofac Res. 2015 Jan-Apr;5(1):46-52. doi: 10.1016/j.jobcr.2015.01.001. Epub 2015 Feb 25.
Abstract
Periodontitis is an inflammatory condition resulting from the interplay between the infectious agents and host factors. Various protein molecules play a vital role in the initiation, progression and severity of periodontal diseases. The study of proteins as biomarkers in periodontal diseases has been highlighted during the last few years. In periodontitis multiple bacteria derived (e.g. collagen degrading enzymes, elastase like enzymes etc) and host derived mediators (eg. PGE2, TNF, IL1, IL6, MMP's etc) expressed in the saliva and gingival crevicular fluid, can be utilized as diagnostic markers for the disease. Another significant development regarding human genes and proteins has been the discovery of potential new drugs for the treatment of periodontal diseases. Therefore the information of the proteins involved in the pathogenesis of periodontal diseases can be utilized for its diagnosis, prevention and treatment.
摘要
牙周炎是一种由感染因子与宿主因素相互作用引起的炎症性疾病。各种蛋白质分子在牙周疾病的发生、发展和严重程度中起着至关重要的作用。在过去几年中，蛋白质作为牙周疾病生物标志物的研究受到了关注。在牙周炎中，唾液和龈沟液中表达的多种细菌衍生介质（如胶原蛋白降解酶、类弹性蛋白酶等）和宿主衍生介质（如前列腺素E2、肿瘤坏死因子、白细胞介素1、白细胞介素6、基质金属蛋白酶等）可作为该疾病的诊断标志物。关于人类基因和蛋白质的另一项重大进展是发现了治疗牙周疾病的潜在新药。因此，参与牙周疾病发病机制的蛋白质信息可用于其诊断、预防和治疗。
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本文引用的文献
1
Immune Response: The Key to Bone Resorption in Periodontal Disease.免疫反应：牙周病中骨吸收的关键
J Periodontol. 2005 Nov;76 Suppl 11S:2033-2041. doi: 10.1902/jop.2005.76.11-S.2033.
2
Identification of azurocidin as a potential periodontitis biomarker by a proteomic analysis of gingival crevicular fluid.通过对牙龈沟液的蛋白质组学分析鉴定天青杀素作为牙周炎潜在生物标志物。
Proteome Sci. 2011 Jul 28;9:42. doi: 10.1186/1477-5956-9-42.
3
Alterations in the salivary proteome associated with periodontitis.与牙周炎相关的唾液蛋白质组的改变。
J Clin Periodontol. 2010 Mar;37(3):241-7. doi: 10.1111/j.1600-051X.2009.01525.x.
4
Proteomics of Porphyromonas gingivalis within a model oral microbial community.口腔微生物群落模型中牙龈卟啉单胞菌的蛋白质组学
BMC Microbiol. 2009 May 19;9:98. doi: 10.1186/1471-2180-9-98.
5
Early osteogenic differential protein profile detected by proteomic analysis in human periodontal ligament cells.通过蛋白质组学分析在人牙周膜细胞中检测到的早期成骨差异蛋白谱
J Periodontal Res. 2009 Oct;44(5):645-56. doi: 10.1111/j.1600-0765.2008.01174.x. Epub 2009 May 18.
6
Saliva as a diagnostic tool for periodontal disease: current state and future directions.唾液作为牙周疾病的诊断工具：现状与未来方向。
Periodontol 2000. 2009;50:52-64. doi: 10.1111/j.1600-0757.2008.00288.x.
7
Bone remodeling biomarkers of periodontal disease in saliva.唾液中牙周疾病的骨重塑生物标志物
J Periodontol. 2008 Oct;79(10):1913-9. doi: 10.1902/jop.2008.080070.
8
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9
The proteomic profile of Fusobacterium nucleatum is regulated by growth pH.具核梭杆菌的蛋白质组图谱受生长pH值调控。
Microbiology (Reading). 2007 Jan;153(Pt 1):148-59. doi: 10.1099/mic.0.2006/001040-0.
10
Mass spectrometry-based proteomics and its application to studies of Porphyromonas gingivalis invasion and pathogenicity.基于质谱的蛋白质组学及其在牙龈卟啉单胞菌侵袭与致病性研究中的应用。
Infect Disord Drug Targets. 2006 Sep;6(3):311-25. doi: 10.2174/187152606778249935.
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