Gupta Abhaya, Govila Vivek, Saini Ashish
MDS (IIIrd Year) Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
MDS (Professor & Head of Department), Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
J Oral Biol Craniofac Res. 2015 Jan-Apr;5(1):46-52. doi: 10.1016/j.jobcr.2015.01.001. Epub 2015 Feb 25.
Periodontitis is an inflammatory condition resulting from the interplay between the infectious agents and host factors. Various protein molecules play a vital role in the initiation, progression and severity of periodontal diseases. The study of proteins as biomarkers in periodontal diseases has been highlighted during the last few years. In periodontitis multiple bacteria derived (e.g. collagen degrading enzymes, elastase like enzymes etc) and host derived mediators (eg. PGE2, TNF, IL1, IL6, MMP's etc) expressed in the saliva and gingival crevicular fluid, can be utilized as diagnostic markers for the disease. Another significant development regarding human genes and proteins has been the discovery of potential new drugs for the treatment of periodontal diseases. Therefore the information of the proteins involved in the pathogenesis of periodontal diseases can be utilized for its diagnosis, prevention and treatment.
牙周炎是一种由感染因子与宿主因素相互作用引起的炎症性疾病。各种蛋白质分子在牙周疾病的发生、发展和严重程度中起着至关重要的作用。在过去几年中，蛋白质作为牙周疾病生物标志物的研究受到了关注。在牙周炎中，唾液和龈沟液中表达的多种细菌衍生介质（如胶原蛋白降解酶、类弹性蛋白酶等）和宿主衍生介质（如前列腺素E2、肿瘤坏死因子、白细胞介素1、白细胞介素6、基质金属蛋白酶等）可作为该疾病的诊断标志物。关于人类基因和蛋白质的另一项重大进展是发现了治疗牙周疾病的潜在新药。因此，参与牙周疾病发病机制的蛋白质信息可用于其诊断、预防和治疗。
